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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUF1
All Species:
21.52
Human Site:
S218
Identified Species:
39.44
UniProt:
Q8N442
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N442
NP_068746.2
669
74328
S218
E
K
V
F
D
I
P
S
D
E
C
I
K
I
S
Chimpanzee
Pan troglodytes
XP_517175
669
74318
S218
E
K
V
F
D
I
P
S
D
E
C
I
K
I
S
Rhesus Macaque
Macaca mulatta
XP_001099650
663
73937
S212
E
K
V
F
D
I
P
S
D
E
C
I
K
I
S
Dog
Lupus familis
XP_539246
890
98288
R439
E
K
V
F
D
I
P
R
N
E
C
I
K
I
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8C3X4
651
72444
S200
E
K
V
F
D
I
P
S
E
E
C
I
K
I
S
Rat
Rattus norvegicus
NP_001100685
659
73188
S208
E
K
V
F
D
I
P
S
E
E
C
I
K
I
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515927
641
71161
A198
Q
D
C
I
R
I
S
A
K
L
G
T
N
V
D
Chicken
Gallus gallus
XP_001232470
660
74204
V209
E
K
L
F
D
I
P
V
N
E
C
I
R
I
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002664348
672
75290
K224
E
T
V
F
D
I
P
K
E
E
C
I
R
I
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_396034
626
70950
I201
H
K
I
L
D
A
I
I
E
R
I
P
P
P
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_791097
640
71703
A199
D
E
V
L
K
I
S
A
K
A
G
T
G
V
D
Poplar Tree
Populus trichocarpa
XP_002323840
611
67671
I193
E
Q
V
L
P
S
V
I
D
R
I
P
P
P
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_198806
663
73577
T221
K
S
M
F
D
L
D
T
E
D
V
L
L
V
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.8
70.1
N.A.
87.5
87.5
N.A.
80.1
77.7
N.A.
74.1
N.A.
N.A.
54.1
N.A.
64.1
Protein Similarity:
100
99.8
97.9
72.5
N.A.
93.4
94
N.A.
87.8
87.5
N.A.
85.5
N.A.
N.A.
69.6
N.A.
79.3
P-Site Identity:
100
100
100
86.6
N.A.
93.3
93.3
N.A.
6.6
73.3
N.A.
73.3
N.A.
N.A.
13.3
N.A.
13.3
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
26.6
93.3
N.A.
86.6
N.A.
N.A.
33.3
N.A.
40
Percent
Protein Identity:
47.6
N.A.
N.A.
55.7
N.A.
N.A.
Protein Similarity:
66.2
N.A.
N.A.
72.6
N.A.
N.A.
P-Site Identity:
26.6
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
73.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
0
16
0
8
0
0
0
0
0
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
62
0
0
0
0
% C
% Asp:
8
8
0
0
77
0
8
0
31
8
0
0
0
0
16
% D
% Glu:
70
8
0
0
0
0
0
0
39
62
0
0
0
0
0
% E
% Phe:
0
0
0
70
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
16
0
8
0
0
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
8
0
77
8
16
0
0
16
62
0
62
0
% I
% Lys:
8
62
0
0
8
0
0
8
16
0
0
0
47
0
0
% K
% Leu:
0
0
8
24
0
8
0
0
0
8
0
8
8
0
0
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
16
0
0
0
8
0
8
% N
% Pro:
0
0
0
0
8
0
62
0
0
0
0
16
16
16
0
% P
% Gln:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
8
0
0
8
0
16
0
0
16
0
0
% R
% Ser:
0
8
0
0
0
8
16
39
0
0
0
0
0
0
77
% S
% Thr:
0
8
0
0
0
0
0
8
0
0
0
16
0
0
0
% T
% Val:
0
0
70
0
0
0
8
8
0
0
8
0
0
24
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _