KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
D2HGDH
All Species:
37.27
Human Site:
S489
Identified Species:
58.57
UniProt:
Q8N465
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N465
NP_689996.4
521
56416
S489
K
R
D
V
L
G
Y
S
K
P
P
G
A
L
Q
Chimpanzee
Pan troglodytes
XP_001162772
466
50496
A443
G
E
R
H
P
G
A
A
V
L
C
V
L
G
G
Rhesus Macaque
Macaca mulatta
XP_001094865
519
56150
S487
K
R
D
V
L
G
Y
S
K
P
P
E
A
L
Q
Dog
Lupus familis
XP_852029
541
59008
S509
K
K
D
A
L
H
Y
S
K
P
P
A
A
L
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIM3
535
58556
S503
K
K
D
V
L
G
Y
S
K
P
P
V
A
V
T
Rat
Rattus norvegicus
P84850
535
58786
S503
K
K
N
V
L
G
Y
S
K
P
P
V
A
V
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422664
541
59236
S509
K
K
Q
F
I
Q
Y
S
K
P
N
E
A
V
F
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A1L258
533
58696
S500
K
R
N
Y
I
Y
Y
S
K
P
S
E
A
V
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V778
631
70803
A581
R
S
H
W
Y
R
N
A
V
T
E
T
G
S
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O45218
597
66541
T559
R
K
Q
W
M
L
T
T
N
G
A
V
G
I
A
Sea Urchin
Strong. purpuratus
XP_783292
557
61383
S524
K
R
N
Y
I
G
L
S
K
A
A
E
A
V
H
Poplar Tree
Populus trichocarpa
XP_002310828
530
58306
S494
K
A
N
E
I
F
Y
S
K
S
H
E
T
V
Q
Maize
Zea mays
NP_001141496
562
61260
S529
K
A
E
K
I
H
Y
S
K
S
P
E
A
V
Q
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23240
559
61427
S524
K
A
N
E
I
F
Y
S
K
S
P
E
T
V
A
Baker's Yeast
Sacchar. cerevisiae
P46681
530
59250
S502
K
K
N
Y
I
G
Y
S
K
S
P
E
E
V
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85
95.5
78.9
N.A.
79.4
79.6
N.A.
N.A.
68.7
N.A.
61.7
N.A.
21.2
N.A.
20.4
53.5
Protein Similarity:
100
86.9
97.1
86.1
N.A.
86.7
87.2
N.A.
N.A.
81.1
N.A.
76.3
N.A.
37
N.A.
38.3
67.8
P-Site Identity:
100
6.6
93.3
66.6
N.A.
73.3
66.6
N.A.
N.A.
40
N.A.
46.6
N.A.
0
N.A.
0
40
P-Site Similarity:
100
13.3
93.3
80
N.A.
86.6
93.3
N.A.
N.A.
60
N.A.
66.6
N.A.
13.3
N.A.
33.3
60
Percent
Protein Identity:
52.2
50.8
N.A.
50.8
50.3
N.A.
Protein Similarity:
68.6
65.8
N.A.
65.6
66.6
N.A.
P-Site Identity:
33.3
46.6
N.A.
33.3
40
N.A.
P-Site Similarity:
53.3
66.6
N.A.
53.3
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
20
0
7
0
0
7
14
0
7
14
7
60
0
20
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
0
0
27
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
7
7
14
0
0
0
0
0
0
7
54
7
0
0
% E
% Phe:
0
0
0
7
0
14
0
0
0
0
0
0
0
0
7
% F
% Gly:
7
0
0
0
0
47
0
0
0
7
0
7
14
7
7
% G
% His:
0
0
7
7
0
14
0
0
0
0
7
0
0
0
7
% H
% Ile:
0
0
0
0
47
0
0
0
0
0
0
0
0
7
0
% I
% Lys:
80
40
0
7
0
0
0
0
80
0
0
0
0
0
14
% K
% Leu:
0
0
0
0
34
7
7
0
0
7
0
0
7
20
0
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
40
0
0
0
7
0
7
0
7
0
0
0
0
% N
% Pro:
0
0
0
0
7
0
0
0
0
47
54
0
0
0
0
% P
% Gln:
0
0
14
0
0
7
0
0
0
0
0
0
0
0
27
% Q
% Arg:
14
27
7
0
0
7
0
0
0
0
0
0
0
0
7
% R
% Ser:
0
7
0
0
0
0
0
80
0
27
7
0
0
7
7
% S
% Thr:
0
0
0
0
0
0
7
7
0
7
0
7
14
0
7
% T
% Val:
0
0
0
27
0
0
0
0
14
0
0
27
0
60
0
% V
% Trp:
0
0
0
14
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
20
7
7
74
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _