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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
D2HGDH
All Species:
30
Human Site:
S60
Identified Species:
47.14
UniProt:
Q8N465
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N465
NP_689996.4
521
56416
S60
P
V
R
R
L
P
F
S
T
V
S
K
Q
D
L
Chimpanzee
Pan troglodytes
XP_001162772
466
50496
V45
S
A
P
G
I
P
E
V
P
L
T
R
E
R
Y
Rhesus Macaque
Macaca mulatta
XP_001094865
519
56150
S58
P
V
R
R
L
P
F
S
T
V
S
E
Q
D
L
Dog
Lupus familis
XP_852029
541
59008
S80
P
V
K
R
L
P
F
S
T
P
S
E
A
D
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIM3
535
58556
S74
P
V
Q
R
L
P
F
S
T
V
S
E
E
D
L
Rat
Rattus norvegicus
P84850
535
58786
S74
P
V
Q
R
L
P
F
S
T
V
S
E
E
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422664
541
59236
S80
G
L
R
R
L
P
F
S
R
L
S
R
G
D
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A1L258
533
58696
S71
A
P
P
R
L
P
F
S
R
V
T
Q
E
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V778
631
70803
V94
E
K
K
F
D
L
R
V
D
T
T
K
Q
Y
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O45218
597
66541
A86
L
S
D
V
I
I
D
A
P
V
E
N
E
D
I
Sea Urchin
Strong. purpuratus
XP_783292
557
61383
Y94
P
D
L
A
R
G
N
Y
S
Q
L
I
D
E
D
Poplar Tree
Populus trichocarpa
XP_002310828
530
58306
S65
V
E
R
N
P
S
F
S
S
L
N
S
D
D
V
Maize
Zea mays
NP_001141496
562
61260
S97
F
Q
R
N
P
A
Y
S
V
L
N
S
D
D
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23240
559
61427
A83
K
C
F
G
S
S
A
A
S
L
I
Q
R
N
P
Baker's Yeast
Sacchar. cerevisiae
P46681
530
59250
K59
V
H
R
D
P
R
F
K
K
L
T
S
D
D
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85
95.5
78.9
N.A.
79.4
79.6
N.A.
N.A.
68.7
N.A.
61.7
N.A.
21.2
N.A.
20.4
53.5
Protein Similarity:
100
86.9
97.1
86.1
N.A.
86.7
87.2
N.A.
N.A.
81.1
N.A.
76.3
N.A.
37
N.A.
38.3
67.8
P-Site Identity:
100
6.6
93.3
73.3
N.A.
80
80
N.A.
N.A.
53.3
N.A.
53.3
N.A.
13.3
N.A.
13.3
6.6
P-Site Similarity:
100
40
100
86.6
N.A.
100
100
N.A.
N.A.
80
N.A.
73.3
N.A.
26.6
N.A.
40
20
Percent
Protein Identity:
52.2
50.8
N.A.
50.8
50.3
N.A.
Protein Similarity:
68.6
65.8
N.A.
65.6
66.6
N.A.
P-Site Identity:
26.6
20
N.A.
0
26.6
N.A.
P-Site Similarity:
53.3
46.6
N.A.
40
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
7
0
7
7
14
0
0
0
0
7
0
0
% A
% Cys:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
7
7
7
0
7
0
7
0
0
0
27
74
7
% D
% Glu:
7
7
0
0
0
0
7
0
0
0
7
27
34
7
0
% E
% Phe:
7
0
7
7
0
0
60
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
0
14
0
7
0
0
0
0
0
0
7
0
0
% G
% His:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
14
7
0
0
0
0
7
7
0
0
14
% I
% Lys:
7
7
14
0
0
0
0
7
7
0
0
14
0
0
0
% K
% Leu:
7
7
7
0
47
7
0
0
0
40
7
0
0
0
47
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
14
0
0
7
0
0
0
14
7
0
7
0
% N
% Pro:
40
7
14
0
20
54
0
0
14
7
0
0
0
0
14
% P
% Gln:
0
7
14
0
0
0
0
0
0
7
0
14
20
0
0
% Q
% Arg:
0
0
40
47
7
7
7
0
14
0
0
14
7
7
0
% R
% Ser:
7
7
0
0
7
14
0
60
20
0
40
20
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
34
7
27
0
0
0
0
% T
% Val:
14
34
0
7
0
0
0
14
7
40
0
0
0
0
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
7
0
0
0
0
0
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _