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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: D2HGDH All Species: 30.91
Human Site: T445 Identified Species: 48.57
UniProt: Q8N465 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8N465 NP_689996.4 521 56416 T445 G N L H L N V T A E A F S P S
Chimpanzee Pan troglodytes XP_001162772 466 50496 V399 A L S R D G Y V Y K Y D L S L
Rhesus Macaque Macaca mulatta XP_001094865 519 56150 T443 G N L H L N V T A E A F S P S
Dog Lupus familis XP_852029 541 59008 T465 G N L H L N V T S E D F S R S
Cat Felis silvestris
Mouse Mus musculus Q8CIM3 535 58556 T459 G N L H L N V T A E A F S R E
Rat Rattus norvegicus P84850 535 58786 T459 G N L H L N V T A E A F S Q E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_422664 541 59236 T465 G N L H L N I T A E S Y S H S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio A1L258 533 58696 T456 G N L H L N I T S P S K D F D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V778 631 70803 T537 F Y F G F R S T D V A D P V E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O45218 597 66541 R515 F Y F G F N A R G L K N G L E
Sea Urchin Strong. purpuratus XP_783292 557 61383 V480 E N L H L N I V T P E Y D S K
Poplar Tree Populus trichocarpa XP_002310828 530 58306 S450 G N L H L N I S A P R Y D D T
Maize Zea mays NP_001141496 562 61260 V485 G N L H L N I V S S K Y D D N
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O23240 559 61427 S480 G N L H L N I S A A E Y N D K
Baker's Yeast Sacchar. cerevisiae P46681 530 59250 A458 G N L H L N V A V R E Y N K N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85 95.5 78.9 N.A. 79.4 79.6 N.A. N.A. 68.7 N.A. 61.7 N.A. 21.2 N.A. 20.4 53.5
Protein Similarity: 100 86.9 97.1 86.1 N.A. 86.7 87.2 N.A. N.A. 81.1 N.A. 76.3 N.A. 37 N.A. 38.3 67.8
P-Site Identity: 100 0 100 80 N.A. 86.6 86.6 N.A. N.A. 73.3 N.A. 46.6 N.A. 13.3 N.A. 6.6 33.3
P-Site Similarity: 100 6.6 100 86.6 N.A. 86.6 86.6 N.A. N.A. 93.3 N.A. 66.6 N.A. 13.3 N.A. 6.6 46.6
Percent
Protein Identity: 52.2 50.8 N.A. 50.8 50.3 N.A.
Protein Similarity: 68.6 65.8 N.A. 65.6 66.6 N.A.
P-Site Identity: 46.6 40 N.A. 46.6 46.6 N.A.
P-Site Similarity: 73.3 66.6 N.A. 73.3 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 0 0 7 7 47 7 34 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 7 0 0 0 7 0 7 14 27 20 7 % D
% Glu: 7 0 0 0 0 0 0 0 0 40 20 0 0 0 27 % E
% Phe: 14 0 14 0 14 0 0 0 0 0 0 34 0 7 0 % F
% Gly: 74 0 0 14 0 7 0 0 7 0 0 0 7 0 0 % G
% His: 0 0 0 80 0 0 0 0 0 0 0 0 0 7 0 % H
% Ile: 0 0 0 0 0 0 40 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 7 14 7 0 7 14 % K
% Leu: 0 7 80 0 80 0 0 0 0 7 0 0 7 7 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 80 0 0 0 87 0 0 0 0 0 7 14 0 14 % N
% Pro: 0 0 0 0 0 0 0 0 0 20 0 0 7 14 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % Q
% Arg: 0 0 0 7 0 7 0 7 0 7 7 0 0 14 0 % R
% Ser: 0 0 7 0 0 0 7 14 20 7 14 0 40 14 27 % S
% Thr: 0 0 0 0 0 0 0 54 7 0 0 0 0 0 7 % T
% Val: 0 0 0 0 0 0 40 20 7 7 0 0 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 14 0 0 0 0 7 0 7 0 7 40 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _