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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
D2HGDH
All Species:
27.02
Human Site:
T516
Identified Species:
42.46
UniProt:
Q8N465
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N465
NP_689996.4
521
56416
T516
G
I
L
N
P
Y
K
T
L
P
S
Q
A
_
_
Chimpanzee
Pan troglodytes
XP_001162772
466
50496
L461
G
H
R
H
P
A
R
L
R
G
R
A
V
_
_
Rhesus Macaque
Macaca mulatta
XP_001094865
519
56150
T514
G
I
L
N
P
Y
K
T
L
P
S
Q
A
_
_
Dog
Lupus familis
XP_852029
541
59008
T536
G
I
L
N
P
Y
K
T
L
P
A
Q
A
_
_
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIM3
535
58556
T530
G
I
L
N
P
Y
K
T
L
P
A
Q
A
_
_
Rat
Rattus norvegicus
P84850
535
58786
T530
G
I
L
N
P
Y
K
T
L
P
A
R
A
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422664
541
59236
T536
G
I
L
N
P
Y
K
T
L
P
S
S
L
_
_
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A1L258
533
58696
T527
G
I
L
N
P
Y
K
T
L
P
D
N
I
N
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V778
631
70803
L608
N
I
F
A
L
G
N
L
L
P
L
E
E
A
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O45218
597
66541
S592
N
L
I
D
I
I
G
S
P
H
C
K
L
_
_
Sea Urchin
Strong. purpuratus
XP_783292
557
61383
V551
G
I
L
N
P
Y
K
V
L
P
H
A
K
S
_
Poplar Tree
Populus trichocarpa
XP_002310828
530
58306
V521
G
I
L
N
P
Y
K
V
L
P
H
S
L
C
S
Maize
Zea mays
NP_001141496
562
61260
V556
S
I
L
N
P
Y
K
V
L
P
Q
S
V
L
_
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23240
559
61427
V551
G
I
L
N
P
Y
K
V
L
P
H
S
L
F
S
Baker's Yeast
Sacchar. cerevisiae
P46681
530
59250
I523
V
H
Y
D
P
N
G
I
L
N
P
Y
K
Y
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85
95.5
78.9
N.A.
79.4
79.6
N.A.
N.A.
68.7
N.A.
61.7
N.A.
21.2
N.A.
20.4
53.5
Protein Similarity:
100
86.9
97.1
86.1
N.A.
86.7
87.2
N.A.
N.A.
81.1
N.A.
76.3
N.A.
37
N.A.
38.3
67.8
P-Site Identity:
100
15.3
100
92.3
N.A.
92.3
84.6
N.A.
N.A.
84.6
N.A.
71.4
N.A.
20
N.A.
0
64.2
P-Site Similarity:
100
30.7
100
100
N.A.
100
100
N.A.
N.A.
84.6
N.A.
71.4
N.A.
26.6
N.A.
38.4
64.2
Percent
Protein Identity:
52.2
50.8
N.A.
50.8
50.3
N.A.
Protein Similarity:
68.6
65.8
N.A.
65.6
66.6
N.A.
P-Site Identity:
60
57.1
N.A.
60
13.3
N.A.
P-Site Similarity:
60
57.1
N.A.
60
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
7
0
0
0
0
20
14
34
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
7
0
0
7
0
% C
% Asp:
0
0
0
14
0
0
0
0
0
0
7
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
7
7
0
0
% E
% Phe:
0
0
7
0
0
0
0
0
0
0
0
0
0
7
0
% F
% Gly:
74
0
0
0
0
7
14
0
0
7
0
0
0
0
0
% G
% His:
0
14
0
7
0
0
0
0
0
7
20
0
0
0
0
% H
% Ile:
0
80
7
0
7
7
0
7
0
0
0
0
7
0
7
% I
% Lys:
0
0
0
0
0
0
74
0
0
0
0
7
14
0
0
% K
% Leu:
0
7
74
0
7
0
0
14
87
0
7
0
27
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
14
0
0
74
0
7
7
0
0
7
0
7
0
7
0
% N
% Pro:
0
0
0
0
87
0
0
0
7
80
7
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
7
27
0
0
7
% Q
% Arg:
0
0
7
0
0
0
7
0
7
0
7
7
0
0
0
% R
% Ser:
7
0
0
0
0
0
0
7
0
0
20
27
0
7
14
% S
% Thr:
0
0
0
0
0
0
0
47
0
0
0
0
0
0
0
% T
% Val:
7
0
0
0
0
0
0
27
0
0
0
0
14
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
74
0
0
0
0
0
7
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
54
74
% _