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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: D2HGDH All Species: 24.85
Human Site: T95 Identified Species: 39.05
UniProt: Q8N465 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.43
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8N465 NP_689996.4 521 56416 T95 P N V D W L R T L R G C S K V
Chimpanzee Pan troglodytes XP_001162772 466 50496 V78 E R I V P G G V I T D P E A L
Rhesus Macaque Macaca mulatta XP_001094865 519 56150 T93 P N V D W I R T L R G S S K V
Dog Lupus familis XP_852029 541 59008 T115 S N V D W L R T V R G C S R V
Cat Felis silvestris
Mouse Mus musculus Q8CIM3 535 58556 T109 C N V D W L K T V R G C S K V
Rat Rattus norvegicus P84850 535 58786 T109 C N V D W L R T V R G C S K V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_422664 541 59236 S115 C N V D W L K S V R G C S E L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio A1L258 533 58696 T106 S N V D W L K T V Q G S S D V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V778 631 70803 K154 I Y S L W H H K F R R I P D L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O45218 597 66541 K130 M I N L R E G K I P R L P D I
Sea Urchin Strong. purpuratus XP_783292 557 61383 I130 A N T D W L R I C K G T S R L
Poplar Tree Populus trichocarpa XP_002310828 530 58306 K101 A N I D W M H K Y K G S S K L
Maize Zea mays NP_001141496 562 61260 K133 A N V D W M G K Y R G A S Q L
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O23240 559 61427 K129 A N T D W M H K Y K G S S K L
Baker's Yeast Sacchar. cerevisiae P46681 530 59250 K97 Y N E D W M R K Y K G Q S K L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85 95.5 78.9 N.A. 79.4 79.6 N.A. N.A. 68.7 N.A. 61.7 N.A. 21.2 N.A. 20.4 53.5
Protein Similarity: 100 86.9 97.1 86.1 N.A. 86.7 87.2 N.A. N.A. 81.1 N.A. 76.3 N.A. 37 N.A. 38.3 67.8
P-Site Identity: 100 0 86.6 80 N.A. 80 86.6 N.A. N.A. 60 N.A. 60 N.A. 13.3 N.A. 0 46.6
P-Site Similarity: 100 20 93.3 93.3 N.A. 93.3 93.3 N.A. N.A. 93.3 N.A. 80 N.A. 20 N.A. 13.3 66.6
Percent
Protein Identity: 52.2 50.8 N.A. 50.8 50.3 N.A.
Protein Similarity: 68.6 65.8 N.A. 65.6 66.6 N.A.
P-Site Identity: 40 46.6 N.A. 40 46.6 N.A.
P-Site Similarity: 66.6 66.6 N.A. 60 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 27 0 0 0 0 0 0 0 0 0 0 7 0 7 0 % A
% Cys: 20 0 0 0 0 0 0 0 7 0 0 34 0 0 0 % C
% Asp: 0 0 0 80 0 0 0 0 0 0 7 0 0 20 0 % D
% Glu: 7 0 7 0 0 7 0 0 0 0 0 0 7 7 0 % E
% Phe: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 7 20 0 0 0 80 0 0 0 0 % G
% His: 0 0 0 0 0 7 20 0 0 0 0 0 0 0 0 % H
% Ile: 7 7 14 0 0 7 0 7 14 0 0 7 0 0 7 % I
% Lys: 0 0 0 0 0 0 20 40 0 27 0 0 0 47 0 % K
% Leu: 0 0 0 14 0 47 0 0 14 0 0 7 0 0 54 % L
% Met: 7 0 0 0 0 27 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 80 7 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 14 0 0 0 7 0 0 0 0 7 0 7 14 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 7 0 7 0 7 0 % Q
% Arg: 0 7 0 0 7 0 40 0 0 54 14 0 0 14 0 % R
% Ser: 14 0 7 0 0 0 0 7 0 0 0 27 80 0 0 % S
% Thr: 0 0 14 0 0 0 0 40 0 7 0 7 0 0 0 % T
% Val: 0 0 54 7 0 0 0 7 34 0 0 0 0 0 40 % V
% Trp: 0 0 0 0 87 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 7 0 0 0 0 0 0 27 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _