KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
D2HGDH
All Species:
42.42
Human Site:
Y337
Identified Species:
66.67
UniProt:
Q8N465
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N465
NP_689996.4
521
56416
Y337
P
V
Q
E
S
P
F
Y
V
L
I
E
T
S
G
Chimpanzee
Pan troglodytes
XP_001162772
466
50496
F296
F
A
E
V
L
Q
T
F
S
T
C
K
G
M
L
Rhesus Macaque
Macaca mulatta
XP_001094865
519
56150
Y335
P
V
Q
E
S
P
F
Y
V
L
I
E
T
S
G
Dog
Lupus familis
XP_852029
541
59008
Y357
P
V
Q
E
S
P
F
Y
V
L
I
E
T
S
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIM3
535
58556
Y351
P
V
Q
E
S
P
F
Y
V
L
V
E
T
S
G
Rat
Rattus norvegicus
P84850
535
58786
Y351
P
V
Q
E
S
P
F
Y
V
L
V
E
T
S
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422664
541
59236
Y357
P
V
R
G
S
P
F
Y
V
L
I
E
T
S
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A1L258
533
58696
Y348
P
I
T
E
C
P
F
Y
I
V
I
E
T
A
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V778
631
70803
W392
L
K
P
E
K
S
W
W
A
S
V
V
D
A
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O45218
597
66541
W369
K
V
A
S
D
S
W
W
A
D
L
K
S
S
V
Sea Urchin
Strong. purpuratus
XP_783292
557
61383
Y372
P
V
S
E
H
P
F
Y
M
L
I
E
T
S
G
Poplar Tree
Populus trichocarpa
XP_002310828
530
58306
Y346
P
S
A
V
H
N
F
Y
V
L
I
E
T
T
G
Maize
Zea mays
NP_001141496
562
61260
Y378
P
A
S
P
Y
K
F
Y
V
L
V
E
T
T
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23240
559
61427
Y373
V
S
S
S
E
N
F
Y
I
L
I
E
T
T
G
Baker's Yeast
Sacchar. cerevisiae
P46681
530
59250
Y341
L
E
D
E
H
P
F
Y
I
L
I
E
T
S
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85
95.5
78.9
N.A.
79.4
79.6
N.A.
N.A.
68.7
N.A.
61.7
N.A.
21.2
N.A.
20.4
53.5
Protein Similarity:
100
86.9
97.1
86.1
N.A.
86.7
87.2
N.A.
N.A.
81.1
N.A.
76.3
N.A.
37
N.A.
38.3
67.8
P-Site Identity:
100
0
100
100
N.A.
93.3
93.3
N.A.
N.A.
86.6
N.A.
60
N.A.
6.6
N.A.
13.3
80
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
N.A.
93.3
N.A.
86.6
N.A.
33.3
N.A.
46.6
86.6
Percent
Protein Identity:
52.2
50.8
N.A.
50.8
50.3
N.A.
Protein Similarity:
68.6
65.8
N.A.
65.6
66.6
N.A.
P-Site Identity:
60
53.3
N.A.
46.6
66.6
N.A.
P-Site Similarity:
66.6
66.6
N.A.
60
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
14
14
0
0
0
0
0
14
0
0
0
0
14
0
% A
% Cys:
0
0
0
0
7
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
0
0
7
0
7
0
0
0
0
7
0
0
7
0
0
% D
% Glu:
0
7
7
60
7
0
0
0
0
0
0
80
0
0
0
% E
% Phe:
7
0
0
0
0
0
80
7
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
7
0
0
0
0
0
0
0
0
7
0
80
% G
% His:
0
0
0
0
20
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
0
0
0
20
0
60
0
0
0
0
% I
% Lys:
7
7
0
0
7
7
0
0
0
0
0
14
0
0
0
% K
% Leu:
14
0
0
0
7
0
0
0
0
74
7
0
0
0
7
% L
% Met:
0
0
0
0
0
0
0
0
7
0
0
0
0
7
7
% M
% Asn:
0
0
0
0
0
14
0
0
0
0
0
0
0
0
0
% N
% Pro:
67
0
7
7
0
60
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
34
0
0
7
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
14
20
14
40
14
0
0
7
7
0
0
7
60
0
% S
% Thr:
0
0
7
0
0
0
7
0
0
7
0
0
80
20
0
% T
% Val:
7
54
0
14
0
0
0
0
54
7
27
7
0
0
7
% V
% Trp:
0
0
0
0
0
0
14
14
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
0
80
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _