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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: D2HGDH All Species: 38.48
Human Site: Y514 Identified Species: 60.48
UniProt: Q8N465 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8N465 NP_689996.4 521 56416 Y514 P K G I L N P Y K T L P S Q A
Chimpanzee Pan troglodytes XP_001162772 466 50496 A459 R H G H R H P A R L R G R A V
Rhesus Macaque Macaca mulatta XP_001094865 519 56150 Y512 P K G I L N P Y K T L P S Q A
Dog Lupus familis XP_852029 541 59008 Y534 P K G I L N P Y K T L P A Q A
Cat Felis silvestris
Mouse Mus musculus Q8CIM3 535 58556 Y528 P K G I L N P Y K T L P A Q A
Rat Rattus norvegicus P84850 535 58786 Y528 P K G I L N P Y K T L P A R A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_422664 541 59236 Y534 P K G I L N P Y K T L P S S L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio A1L258 533 58696 Y525 P K G I L N P Y K T L P D N I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V778 631 70803 G606 P K N I F A L G N L L P L E E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O45218 597 66541 I590 S A N L I D I I G S P H C K L
Sea Urchin Strong. purpuratus XP_783292 557 61383 Y549 P K G I L N P Y K V L P H A K
Poplar Tree Populus trichocarpa XP_002310828 530 58306 Y519 P N G I L N P Y K V L P H S L
Maize Zea mays NP_001141496 562 61260 Y554 P K S I L N P Y K V L P Q S V
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O23240 559 61427 Y549 P K G I L N P Y K V L P H S L
Baker's Yeast Sacchar. cerevisiae P46681 530 59250 N521 L K V H Y D P N G I L N P Y K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85 95.5 78.9 N.A. 79.4 79.6 N.A. N.A. 68.7 N.A. 61.7 N.A. 21.2 N.A. 20.4 53.5
Protein Similarity: 100 86.9 97.1 86.1 N.A. 86.7 87.2 N.A. N.A. 81.1 N.A. 76.3 N.A. 37 N.A. 38.3 67.8
P-Site Identity: 100 13.3 100 93.3 N.A. 93.3 86.6 N.A. N.A. 86.6 N.A. 80 N.A. 33.3 N.A. 0 73.3
P-Site Similarity: 100 26.6 100 100 N.A. 100 100 N.A. N.A. 86.6 N.A. 80 N.A. 40 N.A. 33.3 73.3
Percent
Protein Identity: 52.2 50.8 N.A. 50.8 50.3 N.A.
Protein Similarity: 68.6 65.8 N.A. 65.6 66.6 N.A.
P-Site Identity: 66.6 66.6 N.A. 73.3 20 N.A.
P-Site Similarity: 66.6 66.6 N.A. 73.3 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 0 0 7 0 7 0 0 0 0 20 14 34 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % C
% Asp: 0 0 0 0 0 14 0 0 0 0 0 0 7 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 % E
% Phe: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 74 0 0 0 0 7 14 0 0 7 0 0 0 % G
% His: 0 7 0 14 0 7 0 0 0 0 0 7 20 0 0 % H
% Ile: 0 0 0 80 7 0 7 7 0 7 0 0 0 0 7 % I
% Lys: 0 80 0 0 0 0 0 0 74 0 0 0 0 7 14 % K
% Leu: 7 0 0 7 74 0 7 0 0 14 87 0 7 0 27 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 7 14 0 0 74 0 7 7 0 0 7 0 7 0 % N
% Pro: 80 0 0 0 0 0 87 0 0 0 7 80 7 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 7 27 0 % Q
% Arg: 7 0 0 0 7 0 0 0 7 0 7 0 7 7 0 % R
% Ser: 7 0 7 0 0 0 0 0 0 7 0 0 20 27 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 47 0 0 0 0 0 % T
% Val: 0 0 7 0 0 0 0 0 0 27 0 0 0 0 14 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 0 74 0 0 0 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _