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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
D2HGDH
All Species:
22.12
Human Site:
Y52
Identified Species:
34.76
UniProt:
Q8N465
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N465
NP_689996.4
521
56416
Y52
V
P
L
T
R
E
R
Y
P
V
R
R
L
P
F
Chimpanzee
Pan troglodytes
XP_001162772
466
50496
C37
P
L
A
R
R
G
C
C
S
A
P
G
I
P
E
Rhesus Macaque
Macaca mulatta
XP_001094865
519
56150
Y50
V
P
L
T
R
E
R
Y
P
V
R
R
L
P
F
Dog
Lupus familis
XP_852029
541
59008
Y72
V
A
L
T
Q
E
R
Y
P
V
K
R
L
P
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIM3
535
58556
Y66
V
T
L
T
P
E
R
Y
P
V
Q
R
L
P
F
Rat
Rattus norvegicus
P84850
535
58786
Y66
V
M
L
T
P
E
R
Y
P
V
Q
R
L
P
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422664
541
59236
Y72
V
P
L
T
C
E
R
Y
G
L
R
R
L
P
F
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A1L258
533
58696
A63
A
N
P
A
N
P
S
A
A
P
P
R
L
P
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V778
631
70803
V86
L
P
S
F
T
K
W
V
E
K
K
F
D
L
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O45218
597
66541
K78
G
F
V
S
P
A
Q
K
L
S
D
V
I
I
D
Sea Urchin
Strong. purpuratus
XP_783292
557
61383
F86
V
P
L
T
R
D
R
F
P
D
L
A
R
G
N
Poplar Tree
Populus trichocarpa
XP_002310828
530
58306
K57
S
F
G
S
L
A
T
K
V
E
R
N
P
S
F
Maize
Zea mays
NP_001141496
562
61260
Q89
T
F
G
S
A
A
T
Q
F
Q
R
N
P
A
Y
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23240
559
61427
Y75
V
G
M
L
L
Q
Q
Y
K
C
F
G
S
S
A
Baker's Yeast
Sacchar. cerevisiae
P46681
530
59250
D51
L
T
S
E
N
Y
P
D
V
H
R
D
P
R
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85
95.5
78.9
N.A.
79.4
79.6
N.A.
N.A.
68.7
N.A.
61.7
N.A.
21.2
N.A.
20.4
53.5
Protein Similarity:
100
86.9
97.1
86.1
N.A.
86.7
87.2
N.A.
N.A.
81.1
N.A.
76.3
N.A.
37
N.A.
38.3
67.8
P-Site Identity:
100
13.3
100
80
N.A.
80
80
N.A.
N.A.
80
N.A.
26.6
N.A.
6.6
N.A.
0
46.6
P-Site Similarity:
100
20
100
93.3
N.A.
86.6
86.6
N.A.
N.A.
86.6
N.A.
26.6
N.A.
26.6
N.A.
26.6
60
Percent
Protein Identity:
52.2
50.8
N.A.
50.8
50.3
N.A.
Protein Similarity:
68.6
65.8
N.A.
65.6
66.6
N.A.
P-Site Identity:
13.3
6.6
N.A.
13.3
13.3
N.A.
P-Site Similarity:
20
20
N.A.
33.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
7
7
7
20
0
7
7
7
0
7
0
7
7
% A
% Cys:
0
0
0
0
7
0
7
7
0
7
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
7
0
7
0
7
7
7
7
0
7
% D
% Glu:
0
0
0
7
0
40
0
0
7
7
0
0
0
0
7
% E
% Phe:
0
20
0
7
0
0
0
7
7
0
7
7
0
0
60
% F
% Gly:
7
7
14
0
0
7
0
0
7
0
0
14
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
14
7
0
% I
% Lys:
0
0
0
0
0
7
0
14
7
7
14
0
0
0
0
% K
% Leu:
14
7
47
7
14
0
0
0
7
7
7
0
47
7
0
% L
% Met:
0
7
7
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
0
14
0
0
0
0
0
0
14
0
0
7
% N
% Pro:
7
34
7
0
20
7
7
0
40
7
14
0
20
54
0
% P
% Gln:
0
0
0
0
7
7
14
7
0
7
14
0
0
0
0
% Q
% Arg:
0
0
0
7
27
0
47
0
0
0
40
47
7
7
7
% R
% Ser:
7
0
14
20
0
0
7
0
7
7
0
0
7
14
0
% S
% Thr:
7
14
0
47
7
0
14
0
0
0
0
0
0
0
0
% T
% Val:
54
0
7
0
0
0
0
7
14
34
0
7
0
0
0
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
47
0
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _