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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DTWD1
All Species:
19.39
Human Site:
S249
Identified Species:
38.79
UniProt:
Q8N5C7
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N5C7
NP_001138427.1
304
35248
S249
G
K
P
D
T
F
L
S
T
I
E
A
I
Y
Y
Chimpanzee
Pan troglodytes
XP_510391
226
25925
D172
R
G
K
N
D
D
P
D
K
P
S
F
K
R
K
Rhesus Macaque
Macaca mulatta
XP_001113941
304
35284
S249
G
K
P
D
T
F
L
S
T
I
E
A
I
Y
Y
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q9D8U7
304
34716
S249
G
K
P
D
T
F
L
S
T
I
E
A
I
Y
Y
Rat
Rattus norvegicus
Q6AYF5
304
34884
S249
G
K
P
D
T
F
L
S
T
I
E
A
I
Y
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520515
304
34841
S247
G
Q
P
D
T
F
L
S
T
I
E
A
I
Y
Y
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6DDV1
291
33524
T236
F
W
R
H
Q
K
G
T
P
N
T
Y
L
S
T
Zebra Danio
Brachydanio rerio
Q5XJ56
251
28410
S197
F
W
R
R
Q
K
G
S
P
D
T
Y
L
A
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651693
327
37834
A236
G
S
P
R
W
Y
L
A
T
I
E
A
I
H
Q
Honey Bee
Apis mellifera
XP_624367
267
31856
I213
P
R
W
Y
L
A
T
I
E
A
I
H
Q
F
L
Nematode Worm
Caenorhab. elegans
NP_496093
557
63487
A499
N
V
P
E
T
G
L
A
T
I
E
A
I
Y
Y
Sea Urchin
Strong. purpuratus
XP_787673
347
40065
A270
K
E
D
N
G
L
P
A
S
Y
F
L
R
G
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.3
98
N.A.
N.A.
73.6
75.3
N.A.
64.8
N.A.
55.5
47
N.A.
34.8
39.1
21.3
29.1
Protein Similarity:
100
74.3
99
N.A.
N.A.
86.5
85.1
N.A.
77.6
N.A.
71
60.8
N.A.
54.1
57.2
32.3
46.6
P-Site Identity:
100
0
100
N.A.
N.A.
100
100
N.A.
93.3
N.A.
0
6.6
N.A.
53.3
0
66.6
0
P-Site Similarity:
100
6.6
100
N.A.
N.A.
100
100
N.A.
100
N.A.
13.3
13.3
N.A.
73.3
13.3
80
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
9
0
25
0
9
0
59
0
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
42
9
9
0
9
0
9
0
0
0
0
0
% D
% Glu:
0
9
0
9
0
0
0
0
9
0
59
0
0
0
0
% E
% Phe:
17
0
0
0
0
42
0
0
0
0
9
9
0
9
0
% F
% Gly:
50
9
0
0
9
9
17
0
0
0
0
0
0
9
0
% G
% His:
0
0
0
9
0
0
0
0
0
0
0
9
0
9
0
% H
% Ile:
0
0
0
0
0
0
0
9
0
59
9
0
59
0
0
% I
% Lys:
9
34
9
0
0
17
0
0
9
0
0
0
9
0
9
% K
% Leu:
0
0
0
0
9
9
59
0
0
0
0
9
17
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
9
0
0
17
0
0
0
0
0
9
0
0
0
0
0
% N
% Pro:
9
0
59
0
0
0
17
0
17
9
0
0
0
0
0
% P
% Gln:
0
9
0
0
17
0
0
0
0
0
0
0
9
0
17
% Q
% Arg:
9
9
17
17
0
0
0
0
0
0
0
0
9
9
0
% R
% Ser:
0
9
0
0
0
0
0
50
9
0
9
0
0
9
0
% S
% Thr:
0
0
0
0
50
0
9
9
59
0
17
0
0
0
17
% T
% Val:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
17
9
0
9
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
0
9
0
0
0
9
0
17
0
50
50
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _