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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DHRSX All Species: 26.06
Human Site: S277 Identified Species: 44.1
UniProt: Q8N5I4 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8N5I4 NP_660160.2 330 36443 S277 P D E G A W T S I Y A A V T P
Chimpanzee Pan troglodytes XP_528624 709 76900 S656 P D E G A W T S I Y A A V T P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_852222 387 42342 S329 P D E G A W T S V Y A A V T P
Cat Felis silvestris
Mouse Mus musculus Q8VBZ0 335 35939 L277 P E E G A W T L V Y A A A A P
Rat Rattus norvegicus NP_001101507 316 35239 Q260 P F F K S P W Q G A Q T S L H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506622 336 37117 S263 P D E G A S I S L Y A A L S P
Chicken Gallus gallus Q5F389 414 46711 T359 M Q Q G A A T T V Y C A T A A
Frog Xenopus laevis NP_001087360 327 35999 S275 P D E G A A T S V Y A S V A P
Zebra Danio Brachydanio rerio Q803A8 412 46303 T356 M Q Q G A A T T V Y C A V A P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VLU5 409 46492 C357 A A A T S I Y C A T A N E L T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_798545 322 35072 S253 P Q Q G A Q T S V Y C A V D P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q42536 405 43844 G349 Y V S E S E A G K R L A Q V V
Baker's Yeast Sacchar. cerevisiae Q08651 330 37466 S266 V G F F F G V S N E Q G S L A
Red Bread Mold Neurospora crassa Q92247 412 44615 P334 A I S H L A E P F K K D Q F E
Conservation
Percent
Protein Identity: 100 37.2 N.A. 67.4 N.A. 56.4 39 N.A. 65.4 29.7 63.9 30.1 N.A. 26.4 N.A. N.A. 39.3
Protein Similarity: 100 41.7 N.A. 75.4 N.A. 71.6 53.9 N.A. 77.9 42.5 78.1 41 N.A. 40.5 N.A. N.A. 56.6
P-Site Identity: 100 100 N.A. 93.3 N.A. 66.6 6.6 N.A. 66.6 33.3 73.3 46.6 N.A. 6.6 N.A. N.A. 60
P-Site Similarity: 100 100 N.A. 100 N.A. 80 13.3 N.A. 86.6 53.3 86.6 66.6 N.A. 13.3 N.A. N.A. 73.3
Percent
Protein Identity: N.A. N.A. N.A. 24.6 25.7 23.7
Protein Similarity: N.A. N.A. N.A. 40.2 43 39.3
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 0
P-Site Similarity: N.A. N.A. N.A. 13.3 6.6 0
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 15 8 8 0 65 29 8 0 8 8 50 65 8 29 15 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 22 0 0 0 0 % C
% Asp: 0 36 0 0 0 0 0 0 0 0 0 8 0 8 0 % D
% Glu: 0 8 43 8 0 8 8 0 0 8 0 0 8 0 8 % E
% Phe: 0 8 15 8 8 0 0 0 8 0 0 0 0 8 0 % F
% Gly: 0 8 0 65 0 8 0 8 8 0 0 8 0 0 0 % G
% His: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 8 % H
% Ile: 0 8 0 0 0 8 8 0 15 0 0 0 0 0 0 % I
% Lys: 0 0 0 8 0 0 0 0 8 8 8 0 0 0 0 % K
% Leu: 0 0 0 0 8 0 0 8 8 0 8 0 8 22 0 % L
% Met: 15 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 8 0 0 8 0 0 0 % N
% Pro: 58 0 0 0 0 8 0 8 0 0 0 0 0 0 58 % P
% Gln: 0 22 22 0 0 8 0 8 0 0 15 0 15 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % R
% Ser: 0 0 15 0 22 8 0 50 0 0 0 8 15 8 0 % S
% Thr: 0 0 0 8 0 0 58 15 0 8 0 8 8 22 8 % T
% Val: 8 8 0 0 0 0 8 0 43 0 0 0 43 8 8 % V
% Trp: 0 0 0 0 0 29 8 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 8 0 0 65 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _