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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NGEF
All Species:
21.52
Human Site:
S130
Identified Species:
47.33
UniProt:
Q8N5V2
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N5V2
NP_001107562.1
710
82496
S130
G
A
Q
E
M
S
E
S
S
S
T
P
G
N
G
Chimpanzee
Pan troglodytes
XP_516157
675
77421
S130
G
A
Q
E
M
S
E
S
S
S
T
P
G
N
G
Rhesus Macaque
Macaca mulatta
XP_001114604
712
82436
S133
G
A
Q
K
M
S
E
S
S
S
T
P
G
N
G
Dog
Lupus familis
XP_543291
742
85934
S161
G
A
K
R
T
S
E
S
S
S
T
P
G
N
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8CHT1
710
82180
S128
G
A
Q
E
A
S
E
S
S
S
T
P
G
N
G
Rat
Rattus norvegicus
Q5BKC9
701
80989
S123
G
A
Q
E
A
S
E
S
S
S
T
P
G
N
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520926
611
70617
I84
W
K
N
L
I
E
Q
I
G
L
L
Y
Q
E
Y
Chicken
Gallus gallus
NP_001010841
427
49944
Frog
Xenopus laevis
NP_001128552
856
97785
G286
V
A
T
L
L
H
P
G
M
E
S
D
S
S
W
Zebra Danio
Brachydanio rerio
XP_697546
728
83194
A141
V
R
S
R
S
P
L
A
S
P
G
D
W
P
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_494706
1136
128641
A515
D
S
W
T
P
T
S
A
E
A
I
Q
D
E
P
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.6
96.2
83.9
N.A.
86.1
86.1
N.A.
76
54.7
31.1
43.1
N.A.
N.A.
N.A.
25.9
N.A.
Protein Similarity:
100
89.5
97.6
88.8
N.A.
91.2
90.9
N.A.
81.5
57.7
48.9
62.5
N.A.
N.A.
N.A.
40.1
N.A.
P-Site Identity:
100
100
93.3
80
N.A.
93.3
93.3
N.A.
0
0
6.6
6.6
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
93.3
93.3
N.A.
13.3
0
26.6
13.3
N.A.
N.A.
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
64
0
0
19
0
0
19
0
10
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
0
0
0
0
0
0
0
19
10
0
0
% D
% Glu:
0
0
0
37
0
10
55
0
10
10
0
0
0
19
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
55
0
0
0
0
0
0
10
10
0
10
0
55
0
55
% G
% His:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
10
0
0
10
0
0
10
0
0
0
0
% I
% Lys:
0
10
10
10
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
19
10
0
10
0
0
10
10
0
0
0
0
% L
% Met:
0
0
0
0
28
0
0
0
10
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
0
0
0
0
0
0
0
55
0
% N
% Pro:
0
0
0
0
10
10
10
0
0
10
0
55
0
10
10
% P
% Gln:
0
0
46
0
0
0
10
0
0
0
0
10
10
0
0
% Q
% Arg:
0
10
0
19
0
0
0
0
0
0
0
0
0
0
10
% R
% Ser:
0
10
10
0
10
55
10
55
64
55
10
0
10
10
0
% S
% Thr:
0
0
10
10
10
10
0
0
0
0
55
0
0
0
0
% T
% Val:
19
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
10
0
10
0
0
0
0
0
0
0
0
0
10
0
10
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _