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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF4E3 All Species: 21.21
Human Site: S136 Identified Species: 31.11
UniProt: Q8N5X7 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8N5X7 NP_001128121.1 224 24441 S136 K V P K D S T S T V W K E L L
Chimpanzee Pan troglodytes XP_526229 376 41048 S288 K V P K D S T S T V W K E L L
Rhesus Macaque Macaca mulatta XP_001084944 264 28611 S176 K V P K D S T S T V W K E L L
Dog Lupus familis XP_541806 183 20579 T105 W K E L L L A T I G E Q F T D
Cat Felis silvestris
Mouse Mus musculus Q9DBB5 207 22818 T120 V P K D S T S T V W K E L L L
Rat Rattus norvegicus P63074 217 25035 R123 T L N K Q Q R R S D L D R F W
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509774 252 27662 A164 K V P K E S T A A V W K E L L
Chicken Gallus gallus
Frog Xenopus laevis Q6GR08 218 24796 S130 K V P K E A S S L V W K E L L
Zebra Danio Brachydanio rerio Q66HY7 224 25384 L136 K V P K E S T L A V W K E L L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48598 259 29205 T167 T L N K S S K T D L D N L W L
Honey Bee Apis mellifera XP_392604 210 24074 E127 K C H K S D T E K I W K E M V
Nematode Worm Caenorhab. elegans O61955 248 27791 L121 K Q R R T Q L L D H Y W L E L
Sea Urchin Strong. purpuratus NP_001091926 211 24181 T125 K V Q K Q N T T K L W K E V L
Poplar Tree Populus trichocarpa
Maize Zea mays O81481 218 24452 D132 S C G R G K S D T F W L H T L
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FK59 221 25726 A132 R F S K V V S A R F W E D L L
Baker's Yeast Sacchar. cerevisiae P07260 213 24236 D125 Q L R G K G A D I D E L W L R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 53.1 69.6 75.4 N.A. 87.9 28.1 N.A. 63 N.A. 73.2 70 N.A. 24.7 47.3 28.2 49.5
Protein Similarity: 100 54.5 72.3 78.5 N.A. 90.1 43.7 N.A. 72.2 N.A. 80.8 78.1 N.A. 44.4 64.7 42.7 66.5
P-Site Identity: 100 100 100 0 N.A. 13.3 6.6 N.A. 80 N.A. 73.3 80 N.A. 20 40 13.3 53.3
P-Site Similarity: 100 100 100 13.3 N.A. 40 20 N.A. 93.3 N.A. 93.3 86.6 N.A. 40 60 26.6 80
Percent
Protein Identity: N.A. 29.4 N.A. 28.1 26.3 N.A.
Protein Similarity: N.A. 46.8 N.A. 48.2 43.3 N.A.
P-Site Identity: N.A. 20 N.A. 26.6 6.6 N.A.
P-Site Similarity: N.A. 33.3 N.A. 60 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 7 13 13 13 0 0 0 0 0 0 % A
% Cys: 0 13 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 7 19 7 0 13 13 13 7 7 7 0 7 % D
% Glu: 0 0 7 0 19 0 0 7 0 0 13 13 50 7 0 % E
% Phe: 0 7 0 0 0 0 0 0 0 13 0 0 7 7 0 % F
% Gly: 0 0 7 7 7 7 0 0 0 7 0 0 0 0 0 % G
% His: 0 0 7 0 0 0 0 0 0 7 0 0 7 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 13 7 0 0 0 0 0 % I
% Lys: 57 7 7 69 7 7 7 0 13 0 7 50 0 0 0 % K
% Leu: 0 19 0 7 7 7 7 13 7 13 7 13 19 57 75 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % M
% Asn: 0 0 13 0 0 7 0 0 0 0 0 7 0 0 0 % N
% Pro: 0 7 38 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 7 7 7 0 13 13 0 0 0 0 0 7 0 0 0 % Q
% Arg: 7 0 13 13 0 0 7 7 7 0 0 0 7 0 7 % R
% Ser: 7 0 7 0 19 38 25 25 7 0 0 0 0 0 0 % S
% Thr: 13 0 0 0 7 7 44 25 25 0 0 0 0 13 0 % T
% Val: 7 44 0 0 7 7 0 0 7 38 0 0 0 7 7 % V
% Trp: 7 0 0 0 0 0 0 0 0 7 63 7 7 7 7 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _