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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4E3
All Species:
30.61
Human Site:
S167
Identified Species:
44.89
UniProt:
Q8N5X7
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N5X7
NP_001128121.1
224
24441
S167
E
V
I
G
V
S
V
S
V
R
D
R
E
D
V
Chimpanzee
Pan troglodytes
XP_526229
376
41048
S319
E
V
I
G
V
S
V
S
V
R
D
R
E
D
V
Rhesus Macaque
Macaca mulatta
XP_001084944
264
28611
S207
E
V
I
G
V
S
V
S
V
R
D
R
E
D
V
Dog
Lupus familis
XP_541806
183
20579
V136
D
R
E
D
V
V
Q
V
W
N
V
N
A
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9DBB5
207
22818
V151
I
I
G
V
S
V
S
V
R
D
R
E
D
V
V
Rat
Rattus norvegicus
P63074
217
25035
V154
D
D
V
C
G
A
V
V
N
V
R
A
K
G
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509774
252
27662
S195
E
V
I
G
V
S
V
S
V
R
D
R
E
D
V
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6GR08
218
24796
S161
E
V
I
G
V
S
V
S
V
R
D
R
E
D
I
Zebra Danio
Brachydanio rerio
Q66HY7
224
25384
S167
E
V
V
G
V
S
V
S
V
R
E
R
E
D
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48598
259
29205
I198
I
C
G
A
V
I
N
I
R
G
K
S
N
K
I
Honey Bee
Apis mellifera
XP_392604
210
24074
S158
E
V
C
G
I
T
V
S
I
R
D
R
E
D
L
Nematode Worm
Caenorhab. elegans
O61955
248
27791
R152
C
G
A
V
V
N
V
R
Q
K
G
D
K
V
S
Sea Urchin
Strong. purpuratus
NP_001091926
211
24181
S156
E
I
C
G
V
S
V
S
I
R
N
T
N
D
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81481
218
24452
K163
A
V
V
S
V
R
G
K
Q
E
R
I
A
I
W
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FK59
221
25726
N163
A
V
L
S
V
R
F
N
E
D
I
I
S
V
W
Baker's Yeast
Sacchar. cerevisiae
P07260
213
24236
I156
I
N
G
V
V
L
S
I
R
K
G
G
N
K
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
53.1
69.6
75.4
N.A.
87.9
28.1
N.A.
63
N.A.
73.2
70
N.A.
24.7
47.3
28.2
49.5
Protein Similarity:
100
54.5
72.3
78.5
N.A.
90.1
43.7
N.A.
72.2
N.A.
80.8
78.1
N.A.
44.4
64.7
42.7
66.5
P-Site Identity:
100
100
100
6.6
N.A.
6.6
6.6
N.A.
100
N.A.
93.3
86.6
N.A.
6.6
66.6
13.3
60
P-Site Similarity:
100
100
100
20
N.A.
20
33.3
N.A.
100
N.A.
100
100
N.A.
13.3
93.3
33.3
80
Percent
Protein Identity:
N.A.
29.4
N.A.
28.1
26.3
N.A.
Protein Similarity:
N.A.
46.8
N.A.
48.2
43.3
N.A.
P-Site Identity:
N.A.
13.3
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
20
N.A.
26.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
0
7
7
0
7
0
0
0
0
0
7
13
0
0
% A
% Cys:
7
7
13
7
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
13
7
0
7
0
0
0
0
0
13
38
7
7
50
7
% D
% Glu:
50
0
7
0
0
0
0
0
7
7
7
7
44
0
0
% E
% Phe:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
7
% F
% Gly:
0
7
19
50
7
0
7
0
0
7
13
7
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
19
13
32
0
7
7
0
13
13
0
7
13
0
7
13
% I
% Lys:
0
0
0
0
0
0
0
7
0
13
7
0
13
13
0
% K
% Leu:
0
0
7
0
0
7
0
0
0
0
0
0
0
0
13
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
0
0
7
7
7
7
7
7
7
19
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
7
0
13
0
0
0
0
0
0
% Q
% Arg:
0
7
0
0
0
13
0
7
19
50
19
44
0
0
0
% R
% Ser:
0
0
0
13
7
44
13
50
0
0
0
7
7
7
7
% S
% Thr:
0
0
0
0
0
7
0
0
0
0
0
7
0
0
0
% T
% Val:
0
57
19
19
82
13
63
19
38
7
7
0
0
19
44
% V
% Trp:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
13
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _