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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF4E3 All Species: 34.85
Human Site: Y104 Identified Species: 51.11
UniProt: Q8N5X7 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8N5X7 NP_001128121.1 224 24441 Y104 S L P L R C S Y H L M R G E R
Chimpanzee Pan troglodytes XP_526229 376 41048 Y256 S L P L R C S Y H L M R G E R
Rhesus Macaque Macaca mulatta XP_001084944 264 28611 Y144 S L P L R C S Y H L M R G E R
Dog Lupus familis XP_541806 183 20579 L73 M R G E R R P L W E E E S N A
Cat Felis silvestris
Mouse Mus musculus Q9DBB5 207 22818 H88 L P L R C S Y H L M R G E R R
Rat Rattus norvegicus P63074 217 25035 Y91 N L M P G C D Y S L F K D G I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509774 252 27662 Y132 N L P L R C S Y H L M R E E R
Chicken Gallus gallus
Frog Xenopus laevis Q6GR08 218 24796 Y98 N L P V R W S Y H L M R G E R
Zebra Danio Brachydanio rerio Q66HY7 224 25384 Y104 C L P L R C S Y H L M R G E R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48598 259 29205 Y135 E I K L G S D Y S L F K K N I
Honey Bee Apis mellifera XP_392604 210 24074 Y95 A V Q V R Y S Y H L M R D E R
Nematode Worm Caenorhab. elegans O61955 248 27791 F89 W G S D Y Y L F K E G I K P M
Sea Urchin Strong. purpuratus NP_001091926 211 24181 Y93 D L P L R F S Y H L M R G N V
Poplar Tree Populus trichocarpa
Maize Zea mays O81481 218 24452 F100 K L I V G A D F H C F K N K I
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FK59 221 25726 L100 L L P S P T D L H F F K D G I
Baker's Yeast Sacchar. cerevisiae P07260 213 24236 Y93 E L P L K S D Y H V F R N D V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 53.1 69.6 75.4 N.A. 87.9 28.1 N.A. 63 N.A. 73.2 70 N.A. 24.7 47.3 28.2 49.5
Protein Similarity: 100 54.5 72.3 78.5 N.A. 90.1 43.7 N.A. 72.2 N.A. 80.8 78.1 N.A. 44.4 64.7 42.7 66.5
P-Site Identity: 100 100 100 6.6 N.A. 6.6 26.6 N.A. 86.6 N.A. 80 93.3 N.A. 20 60 0 73.3
P-Site Similarity: 100 100 100 6.6 N.A. 20 40 N.A. 93.3 N.A. 93.3 93.3 N.A. 33.3 80 6.6 73.3
Percent
Protein Identity: N.A. 29.4 N.A. 28.1 26.3 N.A.
Protein Similarity: N.A. 46.8 N.A. 48.2 43.3 N.A.
P-Site Identity: N.A. 13.3 N.A. 20 40 N.A.
P-Site Similarity: N.A. 40 N.A. 26.6 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 0 7 0 0 0 0 0 0 0 0 7 % A
% Cys: 7 0 0 0 7 38 0 0 0 7 0 0 0 0 0 % C
% Asp: 7 0 0 7 0 0 32 0 0 0 0 0 19 7 0 % D
% Glu: 13 0 0 7 0 0 0 0 0 13 7 7 13 44 0 % E
% Phe: 0 0 0 0 0 7 0 13 0 7 32 0 0 0 0 % F
% Gly: 0 7 7 0 19 0 0 0 0 0 7 7 38 13 0 % G
% His: 0 0 0 0 0 0 0 7 69 0 0 0 0 0 0 % H
% Ile: 0 7 7 0 0 0 0 0 0 0 0 7 0 0 25 % I
% Lys: 7 0 7 0 7 0 0 0 7 0 0 25 13 7 0 % K
% Leu: 13 69 7 50 0 0 7 13 7 63 0 0 0 0 0 % L
% Met: 7 0 7 0 0 0 0 0 0 7 50 0 0 0 7 % M
% Asn: 19 0 0 0 0 0 0 0 0 0 0 0 13 19 0 % N
% Pro: 0 7 57 7 7 0 7 0 0 0 0 0 0 7 0 % P
% Gln: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 7 0 7 57 7 0 0 0 0 7 57 0 7 50 % R
% Ser: 19 0 7 7 0 19 50 0 13 0 0 0 7 0 0 % S
% Thr: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % T
% Val: 0 7 0 19 0 0 0 0 0 7 0 0 0 0 13 % V
% Trp: 7 0 0 0 0 7 0 0 7 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 13 7 69 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _