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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4E3
All Species:
34.85
Human Site:
Y104
Identified Species:
51.11
UniProt:
Q8N5X7
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N5X7
NP_001128121.1
224
24441
Y104
S
L
P
L
R
C
S
Y
H
L
M
R
G
E
R
Chimpanzee
Pan troglodytes
XP_526229
376
41048
Y256
S
L
P
L
R
C
S
Y
H
L
M
R
G
E
R
Rhesus Macaque
Macaca mulatta
XP_001084944
264
28611
Y144
S
L
P
L
R
C
S
Y
H
L
M
R
G
E
R
Dog
Lupus familis
XP_541806
183
20579
L73
M
R
G
E
R
R
P
L
W
E
E
E
S
N
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9DBB5
207
22818
H88
L
P
L
R
C
S
Y
H
L
M
R
G
E
R
R
Rat
Rattus norvegicus
P63074
217
25035
Y91
N
L
M
P
G
C
D
Y
S
L
F
K
D
G
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509774
252
27662
Y132
N
L
P
L
R
C
S
Y
H
L
M
R
E
E
R
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6GR08
218
24796
Y98
N
L
P
V
R
W
S
Y
H
L
M
R
G
E
R
Zebra Danio
Brachydanio rerio
Q66HY7
224
25384
Y104
C
L
P
L
R
C
S
Y
H
L
M
R
G
E
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48598
259
29205
Y135
E
I
K
L
G
S
D
Y
S
L
F
K
K
N
I
Honey Bee
Apis mellifera
XP_392604
210
24074
Y95
A
V
Q
V
R
Y
S
Y
H
L
M
R
D
E
R
Nematode Worm
Caenorhab. elegans
O61955
248
27791
F89
W
G
S
D
Y
Y
L
F
K
E
G
I
K
P
M
Sea Urchin
Strong. purpuratus
NP_001091926
211
24181
Y93
D
L
P
L
R
F
S
Y
H
L
M
R
G
N
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81481
218
24452
F100
K
L
I
V
G
A
D
F
H
C
F
K
N
K
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FK59
221
25726
L100
L
L
P
S
P
T
D
L
H
F
F
K
D
G
I
Baker's Yeast
Sacchar. cerevisiae
P07260
213
24236
Y93
E
L
P
L
K
S
D
Y
H
V
F
R
N
D
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
53.1
69.6
75.4
N.A.
87.9
28.1
N.A.
63
N.A.
73.2
70
N.A.
24.7
47.3
28.2
49.5
Protein Similarity:
100
54.5
72.3
78.5
N.A.
90.1
43.7
N.A.
72.2
N.A.
80.8
78.1
N.A.
44.4
64.7
42.7
66.5
P-Site Identity:
100
100
100
6.6
N.A.
6.6
26.6
N.A.
86.6
N.A.
80
93.3
N.A.
20
60
0
73.3
P-Site Similarity:
100
100
100
6.6
N.A.
20
40
N.A.
93.3
N.A.
93.3
93.3
N.A.
33.3
80
6.6
73.3
Percent
Protein Identity:
N.A.
29.4
N.A.
28.1
26.3
N.A.
Protein Similarity:
N.A.
46.8
N.A.
48.2
43.3
N.A.
P-Site Identity:
N.A.
13.3
N.A.
20
40
N.A.
P-Site Similarity:
N.A.
40
N.A.
26.6
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
7
0
0
0
0
0
0
0
0
7
% A
% Cys:
7
0
0
0
7
38
0
0
0
7
0
0
0
0
0
% C
% Asp:
7
0
0
7
0
0
32
0
0
0
0
0
19
7
0
% D
% Glu:
13
0
0
7
0
0
0
0
0
13
7
7
13
44
0
% E
% Phe:
0
0
0
0
0
7
0
13
0
7
32
0
0
0
0
% F
% Gly:
0
7
7
0
19
0
0
0
0
0
7
7
38
13
0
% G
% His:
0
0
0
0
0
0
0
7
69
0
0
0
0
0
0
% H
% Ile:
0
7
7
0
0
0
0
0
0
0
0
7
0
0
25
% I
% Lys:
7
0
7
0
7
0
0
0
7
0
0
25
13
7
0
% K
% Leu:
13
69
7
50
0
0
7
13
7
63
0
0
0
0
0
% L
% Met:
7
0
7
0
0
0
0
0
0
7
50
0
0
0
7
% M
% Asn:
19
0
0
0
0
0
0
0
0
0
0
0
13
19
0
% N
% Pro:
0
7
57
7
7
0
7
0
0
0
0
0
0
7
0
% P
% Gln:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
7
0
7
57
7
0
0
0
0
7
57
0
7
50
% R
% Ser:
19
0
7
7
0
19
50
0
13
0
0
0
7
0
0
% S
% Thr:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% T
% Val:
0
7
0
19
0
0
0
0
0
7
0
0
0
0
13
% V
% Trp:
7
0
0
0
0
7
0
0
7
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
13
7
69
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _