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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4E3
All Species:
31.52
Human Site:
Y208
Identified Species:
46.22
UniProt:
Q8N5X7
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N5X7
NP_001128121.1
224
24441
Y208
I
T
F
K
A
V
F
Y
K
P
H
E
E
H
H
Chimpanzee
Pan troglodytes
XP_526229
376
41048
Y360
I
T
F
K
A
V
F
Y
K
P
H
E
E
H
H
Rhesus Macaque
Macaca mulatta
XP_001084944
264
28611
Y248
I
T
F
K
A
V
F
Y
K
P
H
E
E
H
H
Dog
Lupus familis
XP_541806
183
20579
F176
P
H
E
E
H
H
A
F
E
G
G
R
G
K
H
Cat
Felis silvestris
Mouse
Mus musculus
Q9DBB5
207
22818
Y191
I
A
F
K
A
V
F
Y
K
P
H
E
E
H
H
Rat
Rattus norvegicus
P63074
217
25035
G196
L
P
P
K
I
V
I
G
Y
Q
S
H
A
D
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509774
252
27662
Y236
T
S
F
K
A
A
F
Y
K
P
H
E
E
H
H
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6GR08
218
24796
Y202
T
S
F
K
A
V
F
Y
K
P
H
E
E
H
H
Zebra Danio
Brachydanio rerio
Q66HY7
224
25384
Y208
I
S
F
K
A
V
F
Y
K
P
H
E
E
H
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48598
259
29205
Y239
G
R
N
N
S
L
Q
Y
Q
L
H
K
D
T
M
Honey Bee
Apis mellifera
XP_392604
210
24074
K199
V
N
F
S
E
F
Y
K
P
H
Q
S
H
H
A
Nematode Worm
Caenorhab. elegans
O61955
248
27791
P208
R
T
S
S
T
V
K
P
R
I
C
L
P
A
K
Sea Urchin
Strong. purpuratus
NP_001091926
211
24181
Y197
I
D
F
R
A
T
F
Y
K
P
H
H
Q
H
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81481
218
24452
D204
I
G
F
I
V
H
D
D
A
K
K
M
D
K
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FK59
221
25726
H204
Y
V
M
E
Y
K
P
H
D
A
S
L
R
D
N
Baker's Yeast
Sacchar. cerevisiae
P07260
213
24236
F196
T
D
D
G
H
L
E
F
F
P
H
S
S
A
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
53.1
69.6
75.4
N.A.
87.9
28.1
N.A.
63
N.A.
73.2
70
N.A.
24.7
47.3
28.2
49.5
Protein Similarity:
100
54.5
72.3
78.5
N.A.
90.1
43.7
N.A.
72.2
N.A.
80.8
78.1
N.A.
44.4
64.7
42.7
66.5
P-Site Identity:
100
100
100
6.6
N.A.
93.3
13.3
N.A.
80
N.A.
86.6
93.3
N.A.
13.3
13.3
13.3
60
P-Site Similarity:
100
100
100
26.6
N.A.
93.3
20
N.A.
86.6
N.A.
93.3
100
N.A.
46.6
26.6
20
73.3
Percent
Protein Identity:
N.A.
29.4
N.A.
28.1
26.3
N.A.
Protein Similarity:
N.A.
46.8
N.A.
48.2
43.3
N.A.
P-Site Identity:
N.A.
13.3
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
20
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
50
7
7
0
7
7
0
0
7
13
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
0
13
7
0
0
0
7
7
7
0
0
0
13
13
7
% D
% Glu:
0
0
7
13
7
0
7
0
7
0
0
44
44
0
0
% E
% Phe:
0
0
63
0
0
7
50
13
7
0
0
0
0
0
0
% F
% Gly:
7
7
0
7
0
0
0
7
0
7
7
0
7
0
7
% G
% His:
0
7
0
0
13
13
0
7
0
7
63
13
7
57
50
% H
% Ile:
44
0
0
7
7
0
7
0
0
7
0
0
0
0
0
% I
% Lys:
0
0
0
50
0
7
7
7
50
7
7
7
0
13
7
% K
% Leu:
7
0
0
0
0
13
0
0
0
7
0
13
0
0
0
% L
% Met:
0
0
7
0
0
0
0
0
0
0
0
7
0
0
7
% M
% Asn:
0
7
7
7
0
0
0
0
0
0
0
0
0
0
13
% N
% Pro:
7
7
7
0
0
0
7
7
7
57
0
0
7
0
0
% P
% Gln:
0
0
0
0
0
0
7
0
7
7
7
0
7
0
0
% Q
% Arg:
7
7
0
7
0
0
0
0
7
0
0
7
7
0
0
% R
% Ser:
0
19
7
13
7
0
0
0
0
0
13
13
7
0
0
% S
% Thr:
19
25
0
0
7
7
0
0
0
0
0
0
0
7
7
% T
% Val:
7
7
0
0
7
50
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
7
0
7
57
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _