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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT6
All Species:
28.18
Human Site:
S222
Identified Species:
47.69
UniProt:
Q8N6T7
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N6T7
NP_057623.1
355
39119
S222
T
S
L
Q
I
R
P
S
G
N
L
P
L
A
T
Chimpanzee
Pan troglodytes
XP_001138012
355
39128
S222
T
S
L
Q
I
R
P
S
G
N
L
P
L
A
T
Rhesus Macaque
Macaca mulatta
XP_001101773
355
39109
S222
T
S
L
Q
I
R
P
S
G
N
L
P
L
A
T
Dog
Lupus familis
XP_542163
361
39677
S222
T
S
L
Q
I
R
P
S
G
N
L
P
L
A
T
Cat
Felis silvestris
Mouse
Mus musculus
P59941
334
36901
R220
L
G
T
S
L
Q
I
R
P
S
G
N
L
P
L
Rat
Rattus norvegicus
NP_001026819
330
36346
T212
R
T
A
D
L
S
V
T
L
G
T
S
L
Q
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001034409
357
39056
S222
T
S
L
Q
I
K
P
S
G
N
L
P
L
I
T
Frog
Xenopus laevis
NP_001085592
331
36947
T212
R
K
A
D
L
S
I
T
L
G
T
S
L
Q
I
Zebra Danio
Brachydanio rerio
NP_001002071
354
39667
S222
T
S
L
Q
I
K
P
S
G
D
L
P
L
L
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649990
317
35186
E195
D
W
E
H
D
L
P
E
N
D
L
E
M
G
V
Honey Bee
Apis mellifera
XP_396298
407
45933
S221
T
T
L
Q
I
I
P
S
G
N
L
P
L
Y
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002298870
464
51652
A217
T
S
L
Q
I
T
P
A
C
N
L
P
L
K
C
Maize
Zea mays
NP_001105577
476
53372
A217
T
S
L
Q
I
T
P
A
C
N
M
P
L
M
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_200387
473
52623
A217
T
S
L
Q
I
T
P
A
C
N
L
P
L
K
C
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
91.1
N.A.
83.9
83.3
N.A.
N.A.
68.9
66.1
60
N.A.
43.9
42.7
N.A.
N.A.
Protein Similarity:
100
100
99.4
93.9
N.A.
87.6
86.7
N.A.
N.A.
79.2
76.9
73.2
N.A.
60.2
56.7
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
6.6
6.6
N.A.
N.A.
86.6
6.6
80
N.A.
13.3
80
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
26.6
26.6
N.A.
N.A.
93.3
20
93.3
N.A.
26.6
86.6
N.A.
N.A.
Percent
Protein Identity:
36.2
40.1
N.A.
36.7
N.A.
N.A.
Protein Similarity:
49.7
50.8
N.A.
49.6
N.A.
N.A.
P-Site Identity:
66.6
60
N.A.
66.6
N.A.
N.A.
P-Site Similarity:
73.3
80
N.A.
73.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
15
0
0
0
0
22
0
0
0
0
0
29
0
% A
% Cys:
0
0
0
0
0
0
0
0
22
0
0
0
0
0
15
% C
% Asp:
8
0
0
15
8
0
0
0
0
15
0
0
0
0
0
% D
% Glu:
0
0
8
0
0
0
0
8
0
0
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
0
50
15
8
0
0
8
0
% G
% His:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
72
8
15
0
0
0
0
0
0
8
15
% I
% Lys:
0
8
0
0
0
15
0
0
0
0
0
0
0
15
0
% K
% Leu:
8
0
72
0
22
8
0
0
15
0
72
0
93
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
0
8
8
0
% M
% Asn:
0
0
0
0
0
0
0
0
8
65
0
8
0
0
0
% N
% Pro:
0
0
0
0
0
0
79
0
8
0
0
72
0
8
0
% P
% Gln:
0
0
0
72
0
8
0
0
0
0
0
0
0
15
0
% Q
% Arg:
15
0
0
0
0
29
0
8
0
0
0
0
0
0
0
% R
% Ser:
0
65
0
8
0
15
0
50
0
8
0
15
0
0
8
% S
% Thr:
72
15
8
0
0
22
0
15
0
0
15
0
0
0
50
% T
% Val:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
8
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _