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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT6
All Species:
9.09
Human Site:
S303
Identified Species:
15.38
UniProt:
Q8N6T7
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N6T7
NP_057623.1
355
39119
S303
K
L
E
P
K
E
E
S
P
T
R
I
N
G
S
Chimpanzee
Pan troglodytes
XP_001138012
355
39128
S303
K
L
E
P
K
E
E
S
P
T
R
I
N
G
S
Rhesus Macaque
Macaca mulatta
XP_001101773
355
39109
S303
K
L
E
P
K
E
E
S
P
T
R
I
N
G
S
Dog
Lupus familis
XP_542163
361
39677
A305
E
P
E
P
K
E
E
A
P
A
Q
L
N
G
P
Cat
Felis silvestris
Mouse
Mus musculus
P59941
334
36901
A285
G
P
C
V
L
D
K
A
L
P
P
L
P
R
P
Rat
Rattus norvegicus
NP_001026819
330
36346
G278
L
E
I
P
T
W
D
G
P
R
V
L
E
K
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001034409
357
39056
P308
H
G
L
L
K
E
E
P
F
S
Q
H
N
G
T
Frog
Xenopus laevis
NP_001085592
331
36947
I279
K
I
P
V
W
T
G
I
H
T
K
T
E
P
T
Zebra Danio
Brachydanio rerio
NP_001002071
354
39667
L289
C
E
D
S
G
G
D
L
D
I
L
P
Y
G
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649990
317
35186
V262
I
S
S
Y
V
D
V
V
L
S
K
V
C
K
L
Honey Bee
Apis mellifera
XP_396298
407
45933
L307
R
I
K
E
M
N
V
L
Y
K
K
V
C
K
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002298870
464
51652
N293
S
L
D
E
R
Y
V
N
W
N
L
R
V
A
S
Maize
Zea mays
NP_001105577
476
53372
A411
E
R
E
N
L
P
R
A
E
T
S
I
H
G
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_200387
473
52623
D383
E
E
H
V
E
I
I
D
K
E
A
V
L
Q
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
91.1
N.A.
83.9
83.3
N.A.
N.A.
68.9
66.1
60
N.A.
43.9
42.7
N.A.
N.A.
Protein Similarity:
100
100
99.4
93.9
N.A.
87.6
86.7
N.A.
N.A.
79.2
76.9
73.2
N.A.
60.2
56.7
N.A.
N.A.
P-Site Identity:
100
100
100
53.3
N.A.
0
13.3
N.A.
N.A.
33.3
13.3
6.6
N.A.
0
0
N.A.
N.A.
P-Site Similarity:
100
100
100
80
N.A.
26.6
33.3
N.A.
N.A.
53.3
33.3
26.6
N.A.
26.6
33.3
N.A.
N.A.
Percent
Protein Identity:
36.2
40.1
N.A.
36.7
N.A.
N.A.
Protein Similarity:
49.7
50.8
N.A.
49.6
N.A.
N.A.
P-Site Identity:
13.3
26.6
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
33.3
46.6
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
22
0
8
8
0
0
8
15
% A
% Cys:
8
0
8
0
0
0
0
0
0
0
0
0
15
0
0
% C
% Asp:
0
0
15
0
0
15
15
8
8
0
0
0
0
0
0
% D
% Glu:
22
22
36
15
8
36
36
0
8
8
0
0
15
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
8
8
0
0
8
8
8
8
0
0
0
0
0
50
0
% G
% His:
8
0
8
0
0
0
0
0
8
0
0
8
8
0
0
% H
% Ile:
8
15
8
0
0
8
8
8
0
8
0
29
0
0
8
% I
% Lys:
29
0
8
0
36
0
8
0
8
8
22
0
0
22
0
% K
% Leu:
8
29
8
8
15
0
0
15
15
0
15
22
8
0
8
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
8
0
8
0
8
0
0
36
0
0
% N
% Pro:
0
15
8
36
0
8
0
8
36
8
8
8
8
8
22
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
15
0
0
8
0
% Q
% Arg:
8
8
0
0
8
0
8
0
0
8
22
8
0
8
0
% R
% Ser:
8
8
8
8
0
0
0
22
0
15
8
0
0
0
36
% S
% Thr:
0
0
0
0
8
8
0
0
0
36
0
8
0
0
15
% T
% Val:
0
0
0
22
8
0
22
8
0
0
8
22
8
0
0
% V
% Trp:
0
0
0
0
8
8
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
8
0
0
8
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _