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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT6
All Species:
17.58
Human Site:
S88
Identified Species:
29.74
UniProt:
Q8N6T7
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N6T7
NP_057623.1
355
39119
S88
K
F
D
T
T
F
E
S
A
R
P
T
Q
T
H
Chimpanzee
Pan troglodytes
XP_001138012
355
39128
S88
K
F
D
T
T
F
E
S
A
R
P
T
Q
T
H
Rhesus Macaque
Macaca mulatta
XP_001101773
355
39109
S88
K
F
D
T
T
F
E
S
A
R
P
T
Q
T
H
Dog
Lupus familis
XP_542163
361
39677
S88
K
F
D
T
T
F
E
S
A
R
P
T
Q
T
H
Cat
Felis silvestris
Mouse
Mus musculus
P59941
334
36901
N88
K
F
D
T
T
F
E
N
A
R
P
S
K
T
H
Rat
Rattus norvegicus
NP_001026819
330
36346
N88
K
F
D
I
T
F
E
N
A
R
P
S
K
T
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001034409
357
39056
N88
K
F
D
T
T
F
E
N
A
R
P
S
K
T
H
Frog
Xenopus laevis
NP_001085592
331
36947
T88
K
F
D
T
T
F
E
T
A
C
P
S
P
T
H
Zebra Danio
Brachydanio rerio
NP_001002071
354
39667
D88
H
F
N
T
T
F
E
D
A
R
P
S
L
T
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649990
317
35186
L73
G
P
K
G
V
W
T
L
E
E
K
G
E
K
P
Honey Bee
Apis mellifera
XP_396298
407
45933
E88
T
M
N
I
S
F
D
E
A
I
P
T
K
T
H
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002298870
464
51652
H88
P
E
A
S
L
P
F
H
R
A
M
P
S
M
T
Maize
Zea mays
NP_001105577
476
53372
H88
P
N
A
S
L
P
F
H
H
A
V
P
S
L
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_200387
473
52623
H88
P
K
A
S
L
P
F
H
R
A
M
P
S
M
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
91.1
N.A.
83.9
83.3
N.A.
N.A.
68.9
66.1
60
N.A.
43.9
42.7
N.A.
N.A.
Protein Similarity:
100
100
99.4
93.9
N.A.
87.6
86.7
N.A.
N.A.
79.2
76.9
73.2
N.A.
60.2
56.7
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
80
73.3
N.A.
N.A.
80
73.3
66.6
N.A.
0
40
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
93.3
N.A.
N.A.
100
86.6
80
N.A.
13.3
66.6
N.A.
N.A.
Percent
Protein Identity:
36.2
40.1
N.A.
36.7
N.A.
N.A.
Protein Similarity:
49.7
50.8
N.A.
49.6
N.A.
N.A.
P-Site Identity:
0
0
N.A.
0
N.A.
N.A.
P-Site Similarity:
6.6
6.6
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
22
0
0
0
0
0
72
22
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
0
58
0
0
0
8
8
0
0
0
0
0
0
0
% D
% Glu:
0
8
0
0
0
0
65
8
8
8
0
0
8
0
0
% E
% Phe:
0
65
0
0
0
72
22
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
8
0
0
0
0
0
0
0
8
0
0
0
% G
% His:
8
0
0
0
0
0
0
22
8
0
0
0
0
0
72
% H
% Ile:
0
0
0
15
0
0
0
0
0
8
0
0
0
0
0
% I
% Lys:
58
8
8
0
0
0
0
0
0
0
8
0
29
8
0
% K
% Leu:
0
0
0
0
22
0
0
8
0
0
0
0
8
8
0
% L
% Met:
0
8
0
0
0
0
0
0
0
0
15
0
0
15
0
% M
% Asn:
0
8
15
0
0
0
0
22
0
0
0
0
0
0
0
% N
% Pro:
22
8
0
0
0
22
0
0
0
0
72
22
8
0
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
29
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
15
58
0
0
0
0
0
% R
% Ser:
0
0
0
22
8
0
0
29
0
0
0
36
22
0
0
% S
% Thr:
8
0
0
58
65
0
8
8
0
0
0
36
0
72
22
% T
% Val:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _