KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT6
All Species:
10
Human Site:
T337
Identified Species:
16.92
UniProt:
Q8N6T7
Number Species:
13
Phosphosite Substitution
Charge Score:
0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N6T7
NP_057623.1
355
39119
T337
S
P
K
R
E
R
P
T
S
P
A
P
H
R
P
Chimpanzee
Pan troglodytes
XP_001138012
355
39128
T337
S
P
K
R
E
R
P
T
S
P
A
P
H
R
P
Rhesus Macaque
Macaca mulatta
XP_001101773
355
39109
T337
S
P
K
R
E
R
P
T
S
P
A
P
N
R
P
Dog
Lupus familis
XP_542163
361
39677
D343
S
P
K
R
E
R
L
D
S
P
V
P
H
R
P
Cat
Felis silvestris
Mouse
Mus musculus
P59941
334
36901
P318
Y
K
S
K
P
N
S
P
I
L
H
R
P
P
K
Rat
Rattus norvegicus
NP_001026819
330
36346
D312
G
S
Y
K
P
K
P
D
S
P
V
P
H
R
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001034409
357
39056
D341
K
Q
E
C
P
S
P
D
T
G
P
P
L
T
K
Frog
Xenopus laevis
NP_001085592
331
36947
G312
N
L
D
Q
K
R
E
G
C
K
E
E
S
N
L
Zebra Danio
Brachydanio rerio
NP_001002071
354
39667
H324
K
R
K
R
K
E
Q
H
A
E
E
G
Y
K
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649990
317
35186
P295
K
P
M
E
W
T
I
P
T
S
N
V
N
T
F
Honey Bee
Apis mellifera
XP_396298
407
45933
F342
T
K
T
K
K
Q
A
F
M
I
K
Q
D
I
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002298870
464
51652
P342
N
L
K
R
R
T
A
P
A
E
A
F
E
I
L
Maize
Zea mays
NP_001105577
476
53372
S459
V
E
G
T
D
C
H
S
S
L
P
K
K
L
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_200387
473
52623
L447
N
G
D
L
K
W
K
L
E
G
S
G
T
S
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
91.1
N.A.
83.9
83.3
N.A.
N.A.
68.9
66.1
60
N.A.
43.9
42.7
N.A.
N.A.
Protein Similarity:
100
100
99.4
93.9
N.A.
87.6
86.7
N.A.
N.A.
79.2
76.9
73.2
N.A.
60.2
56.7
N.A.
N.A.
P-Site Identity:
100
100
93.3
80
N.A.
0
46.6
N.A.
N.A.
13.3
6.6
13.3
N.A.
6.6
0
N.A.
N.A.
P-Site Similarity:
100
100
100
80
N.A.
6.6
60
N.A.
N.A.
26.6
26.6
40
N.A.
20
26.6
N.A.
N.A.
Percent
Protein Identity:
36.2
40.1
N.A.
36.7
N.A.
N.A.
Protein Similarity:
49.7
50.8
N.A.
49.6
N.A.
N.A.
P-Site Identity:
20
6.6
N.A.
0
N.A.
N.A.
P-Site Similarity:
33.3
20
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
15
0
15
0
29
0
0
0
0
% A
% Cys:
0
0
0
8
0
8
0
0
8
0
0
0
0
0
0
% C
% Asp:
0
0
15
0
8
0
0
22
0
0
0
0
8
0
0
% D
% Glu:
0
8
8
8
29
8
8
0
8
15
15
8
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
8
0
0
8
% F
% Gly:
8
8
8
0
0
0
0
8
0
15
0
15
0
0
0
% G
% His:
0
0
0
0
0
0
8
8
0
0
8
0
29
0
0
% H
% Ile:
0
0
0
0
0
0
8
0
8
8
0
0
0
15
0
% I
% Lys:
22
15
43
22
29
8
8
0
0
8
8
8
8
8
29
% K
% Leu:
0
15
0
8
0
0
8
8
0
15
0
0
8
8
15
% L
% Met:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
22
0
0
0
0
8
0
0
0
0
8
0
15
8
8
% N
% Pro:
0
36
0
0
22
0
36
22
0
36
15
43
8
8
36
% P
% Gln:
0
8
0
8
0
8
8
0
0
0
0
8
0
0
0
% Q
% Arg:
0
8
0
43
8
36
0
0
0
0
0
8
0
36
8
% R
% Ser:
29
8
8
0
0
8
8
8
43
8
8
0
8
8
0
% S
% Thr:
8
0
8
8
0
15
0
22
15
0
0
0
8
15
0
% T
% Val:
8
0
0
0
0
0
0
0
0
0
15
8
0
0
0
% V
% Trp:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
8
0
0
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _