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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT6
All Species:
49.39
Human Site:
T72
Identified Species:
83.59
UniProt:
Q8N6T7
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N6T7
NP_057623.1
355
39119
T72
R
G
P
H
G
V
W
T
M
E
E
R
G
L
A
Chimpanzee
Pan troglodytes
XP_001138012
355
39128
T72
R
G
P
H
G
V
W
T
M
E
E
R
G
L
A
Rhesus Macaque
Macaca mulatta
XP_001101773
355
39109
T72
R
G
P
H
G
V
W
T
M
E
E
R
G
L
A
Dog
Lupus familis
XP_542163
361
39677
T72
R
G
P
H
G
V
W
T
M
E
E
R
G
L
A
Cat
Felis silvestris
Mouse
Mus musculus
P59941
334
36901
T72
R
G
P
H
G
V
W
T
M
E
E
R
G
L
A
Rat
Rattus norvegicus
NP_001026819
330
36346
T72
R
G
P
H
G
V
W
T
M
E
E
R
G
L
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001034409
357
39056
T72
R
G
P
N
G
V
W
T
M
E
E
K
G
L
S
Frog
Xenopus laevis
NP_001085592
331
36947
T72
R
G
P
N
G
V
W
T
L
E
E
K
G
L
D
Zebra Danio
Brachydanio rerio
NP_001002071
354
39667
T72
R
G
P
N
G
V
W
T
M
E
E
R
G
E
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649990
317
35186
T57
H
T
G
A
G
I
S
T
S
A
G
I
P
D
F
Honey Bee
Apis mellifera
XP_396298
407
45933
T72
R
G
T
N
G
V
W
T
L
E
Q
K
G
L
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002298870
464
51652
T72
R
G
P
K
G
I
W
T
L
Q
R
E
G
K
P
Maize
Zea mays
NP_001105577
476
53372
T72
R
G
P
M
G
V
W
T
L
Q
R
A
G
K
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_200387
473
52623
T72
R
G
P
K
G
I
W
T
L
Q
R
E
G
K
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
91.1
N.A.
83.9
83.3
N.A.
N.A.
68.9
66.1
60
N.A.
43.9
42.7
N.A.
N.A.
Protein Similarity:
100
100
99.4
93.9
N.A.
87.6
86.7
N.A.
N.A.
79.2
76.9
73.2
N.A.
60.2
56.7
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
80
73.3
80
N.A.
13.3
60
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
93.3
86.6
N.A.
20
86.6
N.A.
N.A.
Percent
Protein Identity:
36.2
40.1
N.A.
36.7
N.A.
N.A.
Protein Similarity:
49.7
50.8
N.A.
49.6
N.A.
N.A.
P-Site Identity:
46.6
53.3
N.A.
46.6
N.A.
N.A.
P-Site Similarity:
66.6
66.6
N.A.
66.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
0
0
8
0
8
0
0
43
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
15
% D
% Glu:
0
0
0
0
0
0
0
0
0
72
65
15
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
93
8
0
100
0
0
0
0
0
8
0
93
0
8
% G
% His:
8
0
0
43
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
22
0
0
0
0
0
8
0
0
0
% I
% Lys:
0
0
0
15
0
0
0
0
0
0
0
22
0
22
8
% K
% Leu:
0
0
0
0
0
0
0
0
36
0
0
0
0
65
0
% L
% Met:
0
0
0
8
0
0
0
0
58
0
0
0
0
0
0
% M
% Asn:
0
0
0
29
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
86
0
0
0
0
0
0
0
0
0
8
0
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
22
8
0
0
0
0
% Q
% Arg:
93
0
0
0
0
0
0
0
0
0
22
50
0
0
0
% R
% Ser:
0
0
0
0
0
0
8
0
8
0
0
0
0
0
8
% S
% Thr:
0
8
8
0
0
0
0
100
0
0
0
0
0
0
8
% T
% Val:
0
0
0
0
0
79
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
93
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _