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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT6
All Species:
24.55
Human Site:
Y148
Identified Species:
41.54
UniProt:
Q8N6T7
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N6T7
NP_057623.1
355
39119
Y148
C
A
K
C
K
T
Q
Y
V
R
D
T
V
V
G
Chimpanzee
Pan troglodytes
XP_001138012
355
39128
Y148
C
A
K
C
K
T
Q
Y
V
R
D
T
V
V
G
Rhesus Macaque
Macaca mulatta
XP_001101773
355
39109
Y148
C
A
K
C
K
T
Q
Y
V
R
D
T
V
V
G
Dog
Lupus familis
XP_542163
361
39677
Y148
C
V
K
C
K
T
Q
Y
V
R
D
T
V
V
G
Cat
Felis silvestris
Mouse
Mus musculus
P59941
334
36901
Y148
C
P
K
C
K
T
Q
Y
V
R
D
T
V
V
G
Rat
Rattus norvegicus
NP_001026819
330
36346
E140
H
G
N
M
F
V
E
E
C
P
K
C
K
T
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001034409
357
39056
Y148
C
M
K
C
G
K
Q
Y
V
R
D
A
V
V
G
Frog
Xenopus laevis
NP_001085592
331
36947
E140
H
G
N
M
F
V
E
E
C
S
K
C
A
K
Q
Zebra Danio
Brachydanio rerio
NP_001002071
354
39667
Y148
C
E
K
C
G
K
Q
Y
V
R
D
T
V
V
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649990
317
35186
G123
D
G
L
H
L
K
S
G
L
D
R
K
Y
L
S
Honey Bee
Apis mellifera
XP_396298
407
45933
F148
C
D
K
C
G
R
Q
F
I
R
N
F
A
T
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002298870
464
51652
S144
S
F
M
E
V
C
P
S
C
G
V
E
Y
F
R
Maize
Zea mays
NP_001105577
476
53372
C144
S
F
K
E
I
C
P
C
C
K
T
E
Y
L
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_200387
473
52623
C145
F
M
E
M
C
P
S
C
G
A
E
Y
L
R
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
91.1
N.A.
83.9
83.3
N.A.
N.A.
68.9
66.1
60
N.A.
43.9
42.7
N.A.
N.A.
Protein Similarity:
100
100
99.4
93.9
N.A.
87.6
86.7
N.A.
N.A.
79.2
76.9
73.2
N.A.
60.2
56.7
N.A.
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
0
N.A.
N.A.
73.3
0
80
N.A.
0
33.3
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
6.6
N.A.
N.A.
73.3
6.6
80
N.A.
13.3
53.3
N.A.
N.A.
Percent
Protein Identity:
36.2
40.1
N.A.
36.7
N.A.
N.A.
Protein Similarity:
49.7
50.8
N.A.
49.6
N.A.
N.A.
P-Site Identity:
0
6.6
N.A.
0
N.A.
N.A.
P-Site Similarity:
0
20
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
22
0
0
0
0
0
0
0
8
0
8
15
0
0
% A
% Cys:
58
0
0
58
8
15
0
15
29
0
0
15
0
0
0
% C
% Asp:
8
8
0
0
0
0
0
0
0
8
50
0
0
0
8
% D
% Glu:
0
8
8
15
0
0
15
15
0
0
8
15
0
0
0
% E
% Phe:
8
15
0
0
15
0
0
8
0
0
0
8
0
8
0
% F
% Gly:
0
22
0
0
22
0
0
8
8
8
0
0
0
0
50
% G
% His:
15
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
0
0
8
0
0
0
0
0
0
% I
% Lys:
0
0
65
0
36
22
0
0
0
8
15
8
8
8
8
% K
% Leu:
0
0
8
0
8
0
0
0
8
0
0
0
8
15
0
% L
% Met:
0
15
8
22
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
15
0
0
0
0
0
0
0
8
0
0
0
0
% N
% Pro:
0
8
0
0
0
8
15
0
0
8
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
58
0
0
0
0
0
0
0
15
% Q
% Arg:
0
0
0
0
0
8
0
0
0
58
8
0
0
8
15
% R
% Ser:
15
0
0
0
0
0
15
8
0
8
0
0
0
0
8
% S
% Thr:
0
0
0
0
0
36
0
0
0
0
8
43
0
15
0
% T
% Val:
0
8
0
0
8
15
0
0
50
0
8
0
50
50
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
50
0
0
0
8
22
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _