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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLDN22
All Species:
12.12
Human Site:
S110
Identified Species:
38.1
UniProt:
Q8N7P3
Number Species:
7
Phosphosite Substitution
Charge Score:
0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N7P3
NP_001104789.1
220
24509
S110
D
C
L
R
I
G
E
S
Q
R
D
L
K
R
R
Chimpanzee
Pan troglodytes
XP_001160888
220
24356
S110
D
C
L
R
T
G
E
S
Q
R
D
L
K
R
R
Rhesus Macaque
Macaca mulatta
XP_001092698
219
24294
G110
D
C
L
R
I
G
E
G
Q
R
D
L
K
R
R
Dog
Lupus familis
XP_540034
220
24086
S110
D
C
L
R
L
G
E
S
R
R
G
L
K
K
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9D7U6
220
24292
T110
D
C
L
R
L
G
E
T
Q
E
G
L
K
K
R
Rat
Rattus norvegicus
P56745
211
22824
D110
K
C
M
R
C
L
E
D
D
E
V
Q
K
M
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_425804
217
23649
A108
A
K
K
Q
L
L
L
A
G
G
A
A
F
G
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q9YH91
208
22187
D110
K
C
T
N
C
I
E
D
Q
D
A
K
A
K
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.7
95.4
78.1
N.A.
75.4
34.5
N.A.
N.A.
54
N.A.
32.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
98.1
97.7
85.4
N.A.
83.1
51.3
N.A.
N.A.
64.5
N.A.
51.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
93.3
66.6
N.A.
66.6
26.6
N.A.
N.A.
0
N.A.
20
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
93.3
93.3
86.6
N.A.
86.6
33.3
N.A.
N.A.
20
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
0
0
0
0
0
0
13
0
0
25
13
13
0
13
% A
% Cys:
0
88
0
0
25
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
63
0
0
0
0
0
0
25
13
13
38
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
88
0
0
25
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
13
0
0
% F
% Gly:
0
0
0
0
0
63
0
13
13
13
25
0
0
13
13
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
25
13
0
0
0
0
0
0
0
0
0
% I
% Lys:
25
13
13
0
0
0
0
0
0
0
0
13
75
38
0
% K
% Leu:
0
0
63
0
38
25
13
0
0
0
0
63
0
0
0
% L
% Met:
0
0
13
0
0
0
0
0
0
0
0
0
0
13
0
% M
% Asn:
0
0
0
13
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
13
0
0
0
0
63
0
0
13
0
0
0
% Q
% Arg:
0
0
0
75
0
0
0
0
13
50
0
0
0
38
50
% R
% Ser:
0
0
0
0
0
0
0
38
0
0
0
0
0
0
0
% S
% Thr:
0
0
13
0
13
0
0
13
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
13
0
0
0
13
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
13
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _