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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CCDC46 All Species: 12.73
Human Site: S236 Identified Species: 28
UniProt: Q8N8E3 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8N8E3 NP_001032402.1 955 112749 S236 S L M T P K F S L R K S S S F
Chimpanzee Pan troglodytes XP_001163511 955 112710 S236 S L M T P K L S L R K S S S F
Rhesus Macaque Macaca mulatta XP_001116761 955 112893 S236 S L M T P K F S L R K S S S F
Dog Lupus familis XP_537580 250 29557
Cat Felis silvestris
Mouse Mus musculus Q5PR68 954 112657 S235 S L M T P K G S L R K A S S L
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508857 952 111846 G233 S L M T P K L G L R K S S G F
Chicken Gallus gallus P14105 1959 226485 I855 M A K E E E L I K V K E K Q L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P02566 1966 225108 A939 S E L N D Q L A D N E D R T A
Sea Urchin Strong. purpuratus XP_781919 950 112128 A229 R V S T T K Q A S T R F D W P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LW85 726 81954 Q149 A L Y A L A R Q D T K A A E E
Baker's Yeast Sacchar. cerevisiae P25386 1790 206434 V957 F Q S H D N L V A K L T E K L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 98.6 23.8 N.A. 86.6 N.A. N.A. 75.2 20.7 N.A. N.A. N.A. N.A. N.A. 20.1 41
Protein Similarity: 100 99.9 99.5 25.4 N.A. 93.5 N.A. N.A. 87.7 34.5 N.A. N.A. N.A. N.A. N.A. 33.6 63.8
P-Site Identity: 100 93.3 100 0 N.A. 80 N.A. N.A. 80 6.6 N.A. N.A. N.A. N.A. N.A. 6.6 13.3
P-Site Similarity: 100 93.3 100 0 N.A. 86.6 N.A. N.A. 80 13.3 N.A. N.A. N.A. N.A. N.A. 40 33.3
Percent
Protein Identity: N.A. N.A. N.A. 21.6 21.7 N.A.
Protein Similarity: N.A. N.A. N.A. 40.7 35.8 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 0 10 0 10 0 19 10 0 0 19 10 0 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 19 0 0 0 19 0 0 10 10 0 0 % D
% Glu: 0 10 0 10 10 10 0 0 0 0 10 10 10 10 10 % E
% Phe: 10 0 0 0 0 0 19 0 0 0 0 10 0 0 37 % F
% Gly: 0 0 0 0 0 0 10 10 0 0 0 0 0 10 0 % G
% His: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % I
% Lys: 0 0 10 0 0 55 0 0 10 10 64 0 10 10 0 % K
% Leu: 0 55 10 0 10 0 46 0 46 0 10 0 0 0 28 % L
% Met: 10 0 46 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 10 0 10 0 0 0 10 0 0 0 0 0 % N
% Pro: 0 0 0 0 46 0 0 0 0 0 0 0 0 0 10 % P
% Gln: 0 10 0 0 0 10 10 10 0 0 0 0 0 10 0 % Q
% Arg: 10 0 0 0 0 0 10 0 0 46 10 0 10 0 0 % R
% Ser: 55 0 19 0 0 0 0 37 10 0 0 37 46 37 0 % S
% Thr: 0 0 0 55 10 0 0 0 0 19 0 10 0 10 0 % T
% Val: 0 10 0 0 0 0 0 10 0 10 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _