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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PNPLA1 All Species: 6.67
Human Site: S442 Identified Species: 13.33
UniProt: Q8N8W4 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8N8W4 NP_001139188.1 532 57875 S442 P Q T L P R S S L S A F P A Q
Chimpanzee Pan troglodytes XP_001172868 533 57936 S443 P Q T P P R S S L S A F P A Q
Rhesus Macaque Macaca mulatta XP_001109144 481 53057 L401 F T R A L M C L L P A S R S Q
Dog Lupus familis XP_538884 607 65658 P443 S S A S P A Q P P V E E L G P
Cat Felis silvestris
Mouse Mus musculus Q3V1D5 599 65152 G442 T G S S V P I G S P E S P R L
Rat Rattus norvegicus P0C548 478 52548 S398 V E L R R A Q S L P S V P L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509841 390 42660 G310 S W D E R I L G I L S P A L S
Chicken Gallus gallus XP_425818 376 41593 P296 N G L G K C V P Q Y L A P R F
Frog Xenopus laevis NP_001087449 506 56166 H425 S L P P P L H H A T S Y L S T
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001163445 553 62224 D426 L K M T T H N D A L Y A Y Y Y
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q11186 621 69345 E452 S S T M E K E E H K E I E L S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9T076 349 35046 S269 S M A P K S S S P V S N S P T
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.6 26.6 66.8 N.A. 56.4 29.5 N.A. 28.2 35.9 31.2 N.A. N.A. 25.5 N.A. 25.1 N.A.
Protein Similarity: 100 98.8 42.6 72.8 N.A. 65.6 45.4 N.A. 42.8 50.9 48.6 N.A. N.A. 43.7 N.A. 41.7 N.A.
P-Site Identity: 100 93.3 20 6.6 N.A. 6.6 20 N.A. 0 6.6 6.6 N.A. N.A. 0 N.A. 6.6 N.A.
P-Site Similarity: 100 93.3 26.6 6.6 N.A. 13.3 33.3 N.A. 13.3 6.6 33.3 N.A. N.A. 13.3 N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 20.1 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 32.3 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 17 9 0 17 0 0 17 0 25 17 9 17 0 % A
% Cys: 0 0 0 0 0 9 9 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 9 0 0 0 0 9 0 0 0 0 0 0 0 % D
% Glu: 0 9 0 9 9 0 9 9 0 0 25 9 9 0 0 % E
% Phe: 9 0 0 0 0 0 0 0 0 0 0 17 0 0 9 % F
% Gly: 0 17 0 9 0 0 0 17 0 0 0 0 0 9 0 % G
% His: 0 0 0 0 0 9 9 9 9 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 9 9 0 9 0 0 9 0 0 0 % I
% Lys: 0 9 0 0 17 9 0 0 0 9 0 0 0 0 0 % K
% Leu: 9 9 17 9 9 9 9 9 34 17 9 0 17 25 9 % L
% Met: 0 9 9 9 0 9 0 0 0 0 0 0 0 0 0 % M
% Asn: 9 0 0 0 0 0 9 0 0 0 0 9 0 0 0 % N
% Pro: 17 0 9 25 34 9 0 17 17 25 0 9 42 9 9 % P
% Gln: 0 17 0 0 0 0 17 0 9 0 0 0 0 0 25 % Q
% Arg: 0 0 9 9 17 17 0 0 0 0 0 0 9 17 0 % R
% Ser: 42 17 9 17 0 9 25 34 9 17 34 17 9 17 25 % S
% Thr: 9 9 25 9 9 0 0 0 0 9 0 0 0 0 17 % T
% Val: 9 0 0 0 9 0 9 0 0 17 0 9 0 0 0 % V
% Trp: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 9 9 9 9 9 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _