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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PNPLA1
All Species:
6.36
Human Site:
S444
Identified Species:
12.73
UniProt:
Q8N8W4
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N8W4
NP_001139188.1
532
57875
S444
T
L
P
R
S
S
L
S
A
F
P
A
Q
P
P
Chimpanzee
Pan troglodytes
XP_001172868
533
57936
S445
T
P
P
R
S
S
L
S
A
F
P
A
Q
P
P
Rhesus Macaque
Macaca mulatta
XP_001109144
481
53057
P403
R
A
L
M
C
L
L
P
A
S
R
S
Q
M
P
Dog
Lupus familis
XP_538884
607
65658
V445
A
S
P
A
Q
P
P
V
E
E
L
G
P
E
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q3V1D5
599
65152
P444
S
S
V
P
I
G
S
P
E
S
P
R
L
L
L
Rat
Rattus norvegicus
P0C548
478
52548
P400
L
R
R
A
Q
S
L
P
S
V
P
L
S
C
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509841
390
42660
L312
D
E
R
I
L
G
I
L
S
P
A
L
S
K
A
Chicken
Gallus gallus
XP_425818
376
41593
Y298
L
G
K
C
V
P
Q
Y
L
A
P
R
F
L
P
Frog
Xenopus laevis
NP_001087449
506
56166
T427
P
P
P
L
H
H
A
T
S
Y
L
S
T
S
N
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001163445
553
62224
L428
M
T
T
H
N
D
A
L
Y
A
Y
Y
Y
T
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q11186
621
69345
K454
T
M
E
K
E
E
H
K
E
I
E
L
S
E
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9T076
349
35046
V271
A
P
K
S
S
S
P
V
S
N
S
P
T
V
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
26.6
66.8
N.A.
56.4
29.5
N.A.
28.2
35.9
31.2
N.A.
N.A.
25.5
N.A.
25.1
N.A.
Protein Similarity:
100
98.8
42.6
72.8
N.A.
65.6
45.4
N.A.
42.8
50.9
48.6
N.A.
N.A.
43.7
N.A.
41.7
N.A.
P-Site Identity:
100
93.3
26.6
6.6
N.A.
6.6
20
N.A.
0
13.3
6.6
N.A.
N.A.
0
N.A.
6.6
N.A.
P-Site Similarity:
100
93.3
33.3
6.6
N.A.
13.3
26.6
N.A.
13.3
13.3
33.3
N.A.
N.A.
6.6
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
32.3
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
9
0
17
0
0
17
0
25
17
9
17
0
0
17
% A
% Cys:
0
0
0
9
9
0
0
0
0
0
0
0
0
9
0
% C
% Asp:
9
0
0
0
0
9
0
0
0
0
0
0
0
0
17
% D
% Glu:
0
9
9
0
9
9
0
0
25
9
9
0
0
17
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
17
0
0
9
0
0
% F
% Gly:
0
9
0
0
0
17
0
0
0
0
0
9
0
0
0
% G
% His:
0
0
0
9
9
9
9
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
9
9
0
9
0
0
9
0
0
0
0
0
% I
% Lys:
0
0
17
9
0
0
0
9
0
0
0
0
0
9
0
% K
% Leu:
17
9
9
9
9
9
34
17
9
0
17
25
9
17
9
% L
% Met:
9
9
0
9
0
0
0
0
0
0
0
0
0
9
0
% M
% Asn:
0
0
0
0
9
0
0
0
0
9
0
0
0
0
9
% N
% Pro:
9
25
34
9
0
17
17
25
0
9
42
9
9
17
34
% P
% Gln:
0
0
0
0
17
0
9
0
0
0
0
0
25
0
9
% Q
% Arg:
9
9
17
17
0
0
0
0
0
0
9
17
0
0
0
% R
% Ser:
9
17
0
9
25
34
9
17
34
17
9
17
25
9
9
% S
% Thr:
25
9
9
0
0
0
0
9
0
0
0
0
17
9
0
% T
% Val:
0
0
9
0
9
0
0
17
0
9
0
0
0
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
9
9
9
9
9
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _