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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PNPLA1
All Species:
16.67
Human Site:
T229
Identified Species:
33.33
UniProt:
Q8N8W4
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N8W4
NP_001139188.1
532
57875
T229
L
E
N
I
A
R
M
T
H
A
L
F
P
P
D
Chimpanzee
Pan troglodytes
XP_001172868
533
57936
T230
L
E
N
I
A
R
M
T
H
A
L
F
P
P
D
Rhesus Macaque
Macaca mulatta
XP_001109144
481
53057
Y188
T
I
T
V
S
P
F
Y
G
E
Y
D
I
C
P
Dog
Lupus familis
XP_538884
607
65658
T230
L
E
N
I
A
R
M
T
H
A
L
F
P
P
D
Cat
Felis silvestris
Mouse
Mus musculus
Q3V1D5
599
65152
T229
L
E
N
I
T
R
M
T
H
A
L
F
P
P
D
Rat
Rattus norvegicus
P0C548
478
52548
S185
L
K
N
T
I
T
V
S
P
F
S
G
E
S
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509841
390
42660
N97
L
Y
R
I
L
K
K
N
L
G
Q
H
L
P
A
Chicken
Gallus gallus
XP_425818
376
41593
K83
A
N
A
R
E
A
R
K
T
L
L
G
P
L
S
Frog
Xenopus laevis
NP_001087449
506
56166
S212
E
V
R
L
T
N
T
S
I
Q
F
S
L
G
N
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001163445
553
62224
V213
R
Q
N
I
N
R
F
V
R
I
L
F
P
P
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q11186
621
69345
C239
T
D
D
L
S
R
M
C
L
Q
G
F
G
D
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9T076
349
35046
F56
S
W
S
G
K
N
R
F
L
V
H
D
T
L
Y
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
26.6
66.8
N.A.
56.4
29.5
N.A.
28.2
35.9
31.2
N.A.
N.A.
25.5
N.A.
25.1
N.A.
Protein Similarity:
100
98.8
42.6
72.8
N.A.
65.6
45.4
N.A.
42.8
50.9
48.6
N.A.
N.A.
43.7
N.A.
41.7
N.A.
P-Site Identity:
100
100
0
100
N.A.
93.3
20
N.A.
20
13.3
0
N.A.
N.A.
46.6
N.A.
20
N.A.
P-Site Similarity:
100
100
13.3
100
N.A.
93.3
40
N.A.
26.6
13.3
20
N.A.
N.A.
53.3
N.A.
46.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
32.3
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
9
0
25
9
0
0
0
34
0
0
0
0
17
% A
% Cys:
0
0
0
0
0
0
0
9
0
0
0
0
0
9
0
% C
% Asp:
0
9
9
0
0
0
0
0
0
0
0
17
0
9
42
% D
% Glu:
9
34
0
0
9
0
0
0
0
9
0
0
9
0
0
% E
% Phe:
0
0
0
0
0
0
17
9
0
9
9
50
0
0
0
% F
% Gly:
0
0
0
9
0
0
0
0
9
9
9
17
9
9
0
% G
% His:
0
0
0
0
0
0
0
0
34
0
9
9
0
0
0
% H
% Ile:
0
9
0
50
9
0
0
0
9
9
0
0
9
0
0
% I
% Lys:
0
9
0
0
9
9
9
9
0
0
0
0
0
0
0
% K
% Leu:
50
0
0
17
9
0
0
0
25
9
50
0
17
17
0
% L
% Met:
0
0
0
0
0
0
42
0
0
0
0
0
0
0
0
% M
% Asn:
0
9
50
0
9
17
0
9
0
0
0
0
0
0
9
% N
% Pro:
0
0
0
0
0
9
0
0
9
0
0
0
50
50
9
% P
% Gln:
0
9
0
0
0
0
0
0
0
17
9
0
0
0
0
% Q
% Arg:
9
0
17
9
0
50
17
0
9
0
0
0
0
0
9
% R
% Ser:
9
0
9
0
17
0
0
17
0
0
9
9
0
9
9
% S
% Thr:
17
0
9
9
17
9
9
34
9
0
0
0
9
0
0
% T
% Val:
0
9
0
9
0
0
9
9
0
9
0
0
0
0
0
% V
% Trp:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
0
0
0
0
0
9
0
0
9
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _