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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PNPLA1
All Species:
12.42
Human Site:
Y170
Identified Species:
24.85
UniProt:
Q8N8W4
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N8W4
NP_001139188.1
532
57875
Y170
P
T
Y
R
G
V
R
Y
I
D
G
G
F
T
G
Chimpanzee
Pan troglodytes
XP_001172868
533
57936
R170
P
P
T
Y
R
G
V
R
Y
I
D
G
G
F
T
Rhesus Macaque
Macaca mulatta
XP_001109144
481
53057
E137
S
D
F
Q
S
K
D
E
V
V
D
A
L
I
C
Dog
Lupus familis
XP_538884
607
65658
Y171
P
T
Y
R
G
V
R
Y
I
D
G
G
F
T
G
Cat
Felis silvestris
Mouse
Mus musculus
Q3V1D5
599
65152
Y170
P
T
Y
R
G
E
R
Y
I
D
G
G
F
T
S
Rat
Rattus norvegicus
P0C548
478
52548
S134
V
I
I
S
H
F
S
S
K
D
E
L
I
Q
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509841
390
42660
A46
G
A
R
K
L
C
G
A
S
A
G
A
L
S
C
Chicken
Gallus gallus
XP_425818
376
41593
Q32
L
Y
Q
V
G
V
V
Q
S
L
L
E
L
A
P
Frog
Xenopus laevis
NP_001087449
506
56166
G161
I
I
P
P
S
F
R
G
V
R
Y
V
D
G
G
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001163445
553
62224
F160
V
R
Y
M
D
G
A
F
S
D
N
L
P
I
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q11186
621
69345
Y165
P
K
F
R
G
V
Q
Y
I
D
G
G
V
S
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9T076
349
35046
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
26.6
66.8
N.A.
56.4
29.5
N.A.
28.2
35.9
31.2
N.A.
N.A.
25.5
N.A.
25.1
N.A.
Protein Similarity:
100
98.8
42.6
72.8
N.A.
65.6
45.4
N.A.
42.8
50.9
48.6
N.A.
N.A.
43.7
N.A.
41.7
N.A.
P-Site Identity:
100
13.3
0
100
N.A.
86.6
6.6
N.A.
6.6
13.3
13.3
N.A.
N.A.
13.3
N.A.
60
N.A.
P-Site Similarity:
100
13.3
20
100
N.A.
86.6
6.6
N.A.
20
13.3
20
N.A.
N.A.
20
N.A.
80
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
32.3
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
0
9
9
0
9
0
17
0
9
9
% A
% Cys:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
17
% C
% Asp:
0
9
0
0
9
0
9
0
0
50
17
0
9
0
9
% D
% Glu:
0
0
0
0
0
9
0
9
0
0
9
9
0
0
0
% E
% Phe:
0
0
17
0
0
17
0
9
0
0
0
0
25
9
0
% F
% Gly:
9
0
0
0
42
17
9
9
0
0
42
42
9
9
25
% G
% His:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
9
17
9
0
0
0
0
0
34
9
0
0
9
17
0
% I
% Lys:
0
9
0
9
0
9
0
0
9
0
0
0
0
0
0
% K
% Leu:
9
0
0
0
9
0
0
0
0
9
9
17
25
0
9
% L
% Met:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% N
% Pro:
42
9
9
9
0
0
0
0
0
0
0
0
9
0
9
% P
% Gln:
0
0
9
9
0
0
9
9
0
0
0
0
0
9
0
% Q
% Arg:
0
9
9
34
9
0
34
9
0
9
0
0
0
0
0
% R
% Ser:
9
0
0
9
17
0
9
9
25
0
0
0
0
17
9
% S
% Thr:
0
25
9
0
0
0
0
0
0
0
0
0
0
25
9
% T
% Val:
17
0
0
9
0
34
17
0
17
9
0
9
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
34
9
0
0
0
34
9
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _