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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PNPLA1
All Species:
13.64
Human Site:
Y243
Identified Species:
27.27
UniProt:
Q8N8W4
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N8W4
NP_001139188.1
532
57875
Y243
D
L
V
I
L
H
D
Y
Y
Y
R
G
Y
E
D
Chimpanzee
Pan troglodytes
XP_001172868
533
57936
Y244
D
L
V
I
L
H
D
Y
Y
Y
R
G
Y
E
D
Rhesus Macaque
Macaca mulatta
XP_001109144
481
53057
F202
P
K
V
K
S
T
N
F
L
H
V
D
I
T
K
Dog
Lupus familis
XP_538884
607
65658
Y244
D
L
L
I
L
H
N
Y
Y
Y
R
G
Y
E
D
Cat
Felis silvestris
Mouse
Mus musculus
Q3V1D5
599
65152
Y243
D
L
V
I
L
Q
E
Y
Y
Y
R
G
Y
N
D
Rat
Rattus norvegicus
P0C548
478
52548
S199
D
I
C
P
Q
D
S
S
T
N
I
H
E
L
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509841
390
42660
S111
A
N
A
H
Q
L
V
S
G
K
L
C
I
S
L
Chicken
Gallus gallus
XP_425818
376
41593
A97
S
P
K
C
S
L
L
A
N
I
R
A
V
L
E
Frog
Xenopus laevis
NP_001087449
506
56166
A226
N
L
Y
R
L
T
R
A
L
F
P
P
D
P
T
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001163445
553
62224
F227
R
P
E
F
L
S
K
F
C
Q
Q
G
F
D
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q11186
621
69345
C253
A
L
R
F
L
T
K
C
G
L
A
P
C
I
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9T076
349
35046
A70
Y
F
S
Y
A
K
G
A
D
S
V
L
E
V
N
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
26.6
66.8
N.A.
56.4
29.5
N.A.
28.2
35.9
31.2
N.A.
N.A.
25.5
N.A.
25.1
N.A.
Protein Similarity:
100
98.8
42.6
72.8
N.A.
65.6
45.4
N.A.
42.8
50.9
48.6
N.A.
N.A.
43.7
N.A.
41.7
N.A.
P-Site Identity:
100
100
6.6
86.6
N.A.
80
6.6
N.A.
0
6.6
13.3
N.A.
N.A.
20
N.A.
13.3
N.A.
P-Site Similarity:
100
100
26.6
100
N.A.
86.6
13.3
N.A.
0
13.3
26.6
N.A.
N.A.
46.6
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
32.3
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
0
9
0
9
0
0
25
0
0
9
9
0
0
0
% A
% Cys:
0
0
9
9
0
0
0
9
9
0
0
9
9
0
0
% C
% Asp:
42
0
0
0
0
9
17
0
9
0
0
9
9
9
42
% D
% Glu:
0
0
9
0
0
0
9
0
0
0
0
0
17
25
9
% E
% Phe:
0
9
0
17
0
0
0
17
0
9
0
0
9
0
0
% F
% Gly:
0
0
0
0
0
0
9
0
17
0
0
42
0
0
0
% G
% His:
0
0
0
9
0
25
0
0
0
9
0
9
0
0
0
% H
% Ile:
0
9
0
34
0
0
0
0
0
9
9
0
17
9
0
% I
% Lys:
0
9
9
9
0
9
17
0
0
9
0
0
0
0
9
% K
% Leu:
0
50
9
0
59
17
9
0
17
9
9
9
0
17
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
9
9
0
0
0
0
17
0
9
9
0
0
0
9
9
% N
% Pro:
9
17
0
9
0
0
0
0
0
0
9
17
0
9
0
% P
% Gln:
0
0
0
0
17
9
0
0
0
9
9
0
0
0
0
% Q
% Arg:
9
0
9
9
0
0
9
0
0
0
42
0
0
0
17
% R
% Ser:
9
0
9
0
17
9
9
17
0
9
0
0
0
9
0
% S
% Thr:
0
0
0
0
0
25
0
0
9
0
0
0
0
9
9
% T
% Val:
0
0
34
0
0
0
9
0
0
0
17
0
9
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
9
9
0
0
0
34
34
34
0
0
34
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _