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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF1AD
All Species:
21.49
Human Site:
S159
Identified Species:
39.4
UniProt:
Q8N9N8
Number Species:
12
Phosphosite Substitution
Charge Score:
0.42
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N9N8
NP_115701.2
165
19053
S159
Y
H
E
S
E
E
E
S
E
E
E
E
A
A
_
Chimpanzee
Pan troglodytes
XP_508567
166
19149
S160
Y
H
E
S
E
E
E
S
E
E
E
E
A
A
_
Rhesus Macaque
Macaca mulatta
XP_001111707
165
19065
S159
Y
H
E
S
E
E
E
S
E
E
E
E
A
T
_
Dog
Lupus familis
XP_533226
166
19133
S160
Y
Y
E
S
E
E
E
S
E
E
E
E
A
A
_
Cat
Felis silvestris
Mouse
Mus musculus
Q3THJ3
170
19502
S159
Y
H
E
S
E
E
E
S
E
E
D
E
E
E
E
Rat
Rattus norvegicus
Q5RKI6
167
19057
S159
Y
H
E
S
E
E
E
S
E
E
E
E
E
E
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q6K1L7
188
21217
P159
E
E
E
D
R
E
E
P
L
E
D
R
P
E
D
Frog
Xenopus laevis
Q5HZM1
169
19095
E159
V
H
Y
E
D
S
E
E
E
S
E
S
E
E
D
Zebra Danio
Brachydanio rerio
Q7SY07
172
19775
E159
V
L
Y
S
E
S
E
E
E
T
D
E
D
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q8IQ13
159
18519
E150
R
D
S
S
D
E
E
E
D
E
E
T
S
S
E
Honey Bee
Apis mellifera
XP_001120246
155
18102
S145
Q
N
R
I
D
N
T
S
N
I
S
S
E
E
S
Nematode Worm
Caenorhab. elegans
Q23646
175
20401
E159
D
D
V
D
D
E
E
E
E
E
F
D
T
Y
N
Sea Urchin
Strong. purpuratus
XP_784016
211
24540
E159
E
Q
E
E
E
E
D
E
E
D
Y
S
S
E
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
99.3
96.9
N.A.
89.4
91
N.A.
N.A.
48.9
62.1
59.2
N.A.
38.7
40
33.7
42.1
Protein Similarity:
100
99.4
99.3
98.1
N.A.
93.5
95.2
N.A.
N.A.
63.2
76.3
72.6
N.A.
62.4
63
54.8
59.2
P-Site Identity:
100
100
92.8
92.8
N.A.
73.3
80
N.A.
N.A.
26.6
26.6
33.3
N.A.
33.3
6.6
26.6
26.6
P-Site Similarity:
100
100
92.8
100
N.A.
80
80
N.A.
N.A.
33.3
33.3
40
N.A.
60
20
40
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
31
24
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
16
0
16
31
0
8
0
8
8
24
8
8
0
24
% D
% Glu:
16
8
62
16
62
77
85
39
77
70
54
54
31
54
24
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
47
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
8
0
0
0
0
0
0
8
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
8
0
0
8
0
0
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% P
% Gln:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
8
0
8
0
0
0
0
0
0
8
0
0
0
% R
% Ser:
0
0
8
62
0
16
0
54
0
8
8
24
16
8
8
% S
% Thr:
0
0
0
0
0
0
8
0
0
8
0
8
8
8
0
% T
% Val:
16
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
47
8
16
0
0
0
0
0
0
0
8
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
31
% _