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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ANKLE1
All Species:
9.09
Human Site:
S291
Identified Species:
28.57
UniProt:
Q8NAG6
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NAG6
NP_689576.4
575
62235
S291
L
D
R
S
P
A
H
S
P
P
R
T
P
P
P
Chimpanzee
Pan troglodytes
XP_001173375
575
62144
S291
L
D
R
S
P
A
H
S
P
P
R
T
P
P
P
Rhesus Macaque
Macaca mulatta
XP_001114324
683
73209
S373
L
D
R
S
P
A
H
S
P
P
Q
T
P
P
P
Dog
Lupus familis
XP_852664
443
49437
R219
G
P
I
T
P
F
T
R
P
Y
H
L
Q
R
L
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519527
622
67527
E290
V
Q
R
W
F
T
E
E
E
E
S
W
M
P
Q
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395966
443
50476
I219
P
C
K
S
A
N
S
I
S
S
E
K
L
W
P
Nematode Worm
Caenorhab. elegans
NP_492539
732
81526
L377
L
G
N
N
M
E
K
L
N
I
E
S
K
S
A
Sea Urchin
Strong. purpuratus
XP_781548
802
88988
A445
E
E
Q
T
V
P
E
A
C
E
A
S
P
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.5
79.6
54.9
N.A.
N.A.
N.A.
N.A.
26.3
N.A.
N.A.
N.A.
N.A.
N.A.
26.9
21
31.4
Protein Similarity:
100
98.2
81.2
60.7
N.A.
N.A.
N.A.
N.A.
38.9
N.A.
N.A.
N.A.
N.A.
N.A.
41.9
34.2
43
P-Site Identity:
100
100
93.3
13.3
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
6.6
6.6
P-Site Similarity:
100
100
100
20
N.A.
N.A.
N.A.
N.A.
20
N.A.
N.A.
N.A.
N.A.
N.A.
20
20
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
13
38
0
13
0
0
13
0
0
0
13
% A
% Cys:
0
13
0
0
0
0
0
0
13
0
0
0
0
0
0
% C
% Asp:
0
38
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
13
13
0
0
0
13
25
13
13
25
25
0
0
0
0
% E
% Phe:
0
0
0
0
13
13
0
0
0
0
0
0
0
0
0
% F
% Gly:
13
13
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
38
0
0
0
13
0
0
0
0
% H
% Ile:
0
0
13
0
0
0
0
13
0
13
0
0
0
0
0
% I
% Lys:
0
0
13
0
0
0
13
0
0
0
0
13
13
0
0
% K
% Leu:
50
0
0
0
0
0
0
13
0
0
0
13
13
0
13
% L
% Met:
0
0
0
0
13
0
0
0
0
0
0
0
13
0
0
% M
% Asn:
0
0
13
13
0
13
0
0
13
0
0
0
0
0
0
% N
% Pro:
13
13
0
0
50
13
0
0
50
38
0
0
50
50
50
% P
% Gln:
0
13
13
0
0
0
0
0
0
0
13
0
13
0
13
% Q
% Arg:
0
0
50
0
0
0
0
13
0
0
25
0
0
13
0
% R
% Ser:
0
0
0
50
0
0
13
38
13
13
13
25
0
25
13
% S
% Thr:
0
0
0
25
0
13
13
0
0
0
0
38
0
0
0
% T
% Val:
13
0
0
0
13
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
13
0
0
0
0
0
0
0
13
0
13
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
13
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _