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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ANKLE1
All Species:
13.03
Human Site:
T421
Identified Species:
40.95
UniProt:
Q8NAG6
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NAG6
NP_689576.4
575
62235
T421
L
L
L
D
P
R
E
T
Q
D
L
P
A
R
A
Chimpanzee
Pan troglodytes
XP_001173375
575
62144
T421
L
L
L
D
P
R
E
T
Q
D
L
P
A
R
A
Rhesus Macaque
Macaca mulatta
XP_001114324
683
73209
T529
L
L
L
D
P
R
E
T
Q
D
L
P
A
R
A
Dog
Lupus familis
XP_852664
443
49437
L330
R
A
R
P
D
F
H
L
R
E
A
L
R
L
H
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519527
622
67527
G465
V
P
G
R
P
A
A
G
S
P
M
V
P
R
G
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395966
443
50476
P330
G
K
G
T
R
N
R
P
Y
S
H
L
K
D
A
Nematode Worm
Caenorhab. elegans
NP_492539
732
81526
L559
G
Y
N
A
F
C
Y
L
I
M
D
P
R
I
L
Sea Urchin
Strong. purpuratus
XP_781548
802
88988
T650
L
L
L
D
P
R
V
T
R
D
L
P
S
R
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.5
79.6
54.9
N.A.
N.A.
N.A.
N.A.
26.3
N.A.
N.A.
N.A.
N.A.
N.A.
26.9
21
31.4
Protein Similarity:
100
98.2
81.2
60.7
N.A.
N.A.
N.A.
N.A.
38.9
N.A.
N.A.
N.A.
N.A.
N.A.
41.9
34.2
43
P-Site Identity:
100
100
100
0
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
6.6
73.3
P-Site Similarity:
100
100
100
13.3
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
6.6
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
13
0
13
0
13
13
0
0
0
13
0
38
0
50
% A
% Cys:
0
0
0
0
0
13
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
50
13
0
0
0
0
50
13
0
0
13
0
% D
% Glu:
0
0
0
0
0
0
38
0
0
13
0
0
0
0
0
% E
% Phe:
0
0
0
0
13
13
0
0
0
0
0
0
0
0
0
% F
% Gly:
25
0
25
0
0
0
0
13
0
0
0
0
0
0
13
% G
% His:
0
0
0
0
0
0
13
0
0
0
13
0
0
0
13
% H
% Ile:
0
0
0
0
0
0
0
0
13
0
0
0
0
13
0
% I
% Lys:
0
13
0
0
0
0
0
0
0
0
0
0
13
0
0
% K
% Leu:
50
50
50
0
0
0
0
25
0
0
50
25
0
13
13
% L
% Met:
0
0
0
0
0
0
0
0
0
13
13
0
0
0
0
% M
% Asn:
0
0
13
0
0
13
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
13
0
13
63
0
0
13
0
13
0
63
13
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
38
0
0
0
0
0
0
% Q
% Arg:
13
0
13
13
13
50
13
0
25
0
0
0
25
63
0
% R
% Ser:
0
0
0
0
0
0
0
0
13
13
0
0
13
0
0
% S
% Thr:
0
0
0
13
0
0
0
50
0
0
0
0
0
0
0
% T
% Val:
13
0
0
0
0
0
13
0
0
0
0
13
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
13
0
0
0
0
13
0
13
0
0
0
0
0
13
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _