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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRPF38A All Species: 18.18
Human Site: S236 Identified Species: 33.33
UniProt: Q8NAV1 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8NAV1 NP_116253.2 312 37477 S236 L R Y R R S R S R S P R R R S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001111695 312 37444 S236 L R Y R R S R S R S P R R R S
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q4FK66 312 37418 S236 L R Y R R S R S R S P R R R S
Rat Rattus norvegicus Q6AXY7 542 63914 S394 E R S K E Q R S R G E G E E K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001234245 312 37442 S236 I R Y R R S R S R S P R R R S
Frog Xenopus laevis Q4FZQ6 312 37276 R236 R Y R R S R S R S P R R R S R
Zebra Danio Brachydanio rerio Q6DHU4 313 37532 S236 P R Y R R S R S P R R R S R S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610463 330 40069 G236 R E R R S G Q G N S A R S R D
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23121 312 35023 K235 S R S S S R S K S R S R S P P
Sea Urchin Strong. purpuratus XP_781290 318 36969 Q236 S T V D A K I Q S I P G G R R
Poplar Tree Populus trichocarpa XP_002319497 297 35725 L222 R D R D R Y R L R D E R D Y G
Maize Zea mays NP_001151258 389 46781 N236 D R K H E R H N R D K D Y D R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565937 355 43154 G256 R D Y E R E R G H G R D R D R
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 99.6 N.A. N.A. 98.7 23.6 N.A. N.A. 97.7 91.6 88.5 N.A. 53.6 N.A. 20.5 51.2
Protein Similarity: 100 N.A. 99.6 N.A. N.A. 99 35.6 N.A. N.A. 99 96.7 96.1 N.A. 67.5 N.A. 33.9 64.4
P-Site Identity: 100 N.A. 100 N.A. N.A. 100 26.6 N.A. N.A. 93.3 20 66.6 N.A. 26.6 N.A. 13.3 13.3
P-Site Similarity: 100 N.A. 100 N.A. N.A. 100 33.3 N.A. N.A. 100 20 66.6 N.A. 33.3 N.A. 13.3 13.3
Percent
Protein Identity: 54.1 48.3 N.A. 47.3 N.A. N.A.
Protein Similarity: 66.9 58.6 N.A. 62.5 N.A. N.A.
P-Site Identity: 26.6 13.3 N.A. 26.6 N.A. N.A.
P-Site Similarity: 26.6 20 N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 0 0 0 0 0 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 16 0 16 0 0 0 0 0 16 0 16 8 16 8 % D
% Glu: 8 8 0 8 16 8 0 0 0 0 16 0 8 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 8 0 16 0 16 0 16 8 0 8 % G
% His: 0 0 0 8 0 0 8 0 8 0 0 0 0 0 0 % H
% Ile: 8 0 0 0 0 0 8 0 0 8 0 0 0 0 0 % I
% Lys: 0 0 8 8 0 8 0 8 0 0 8 0 0 0 8 % K
% Leu: 24 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 8 8 0 0 0 0 0 0 % N
% Pro: 8 0 0 0 0 0 0 0 8 8 39 0 0 8 8 % P
% Gln: 0 0 0 0 0 8 8 8 0 0 0 0 0 0 0 % Q
% Arg: 31 62 24 54 54 24 62 8 54 16 24 70 47 54 31 % R
% Ser: 16 0 16 8 24 39 16 47 24 39 8 0 24 8 39 % S
% Thr: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 47 0 0 8 0 0 0 0 0 0 8 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _