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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MLKL All Species: 13.33
Human Site: T355 Identified Species: 41.9
UniProt: Q8NB16 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8NB16 NP_689862.1 471 54479 T355 A G F E L R K T Q T S M S L G
Chimpanzee Pan troglodytes XP_001137657 471 54422 T355 A G F E L R E T Q T S M S L G
Rhesus Macaque Macaca mulatta XP_001108382 470 54717 T354 A G F E L R K T Q T S I S L K
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q9D2Y4 472 54299 N344 F E L S K T Q N S I S R T A K
Rat Rattus norvegicus XP_001075467 464 53291 T344 F E L S K T Q T S I S R A T K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512485 545 62578 T410 A G L E L S Q T E S S I S R N
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002314950 781 86168 L650 G D F G L S R L K H E T Y L T
Maize Zea mays NP_001148926 423 46385 M313 Y R W M A P E M I Q H R P Y N
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.6 90.4 N.A. N.A. 61.8 62 N.A. 44.9 N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.5 95.5 N.A. N.A. 77.5 77.4 N.A. 61.8 N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 93.3 86.6 N.A. N.A. 6.6 13.3 N.A. 46.6 N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 93.3 N.A. N.A. 20 26.6 N.A. 73.3 N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: 20.6 23.1 N.A. N.A. N.A. N.A.
Protein Similarity: 34.7 43.1 N.A. N.A. N.A. N.A.
P-Site Identity: 20 0 N.A. N.A. N.A. N.A.
P-Site Similarity: 33.3 13.3 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 50 0 0 0 13 0 0 0 0 0 0 0 13 13 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 13 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 25 0 50 0 0 25 0 13 0 13 0 0 0 0 % E
% Phe: 25 0 50 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 13 50 0 13 0 0 0 0 0 0 0 0 0 0 25 % G
% His: 0 0 0 0 0 0 0 0 0 13 13 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 13 25 0 25 0 0 0 % I
% Lys: 0 0 0 0 25 0 25 0 13 0 0 0 0 0 38 % K
% Leu: 0 0 38 0 63 0 0 13 0 0 0 0 0 50 0 % L
% Met: 0 0 0 13 0 0 0 13 0 0 0 25 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 13 0 0 0 0 0 0 25 % N
% Pro: 0 0 0 0 0 13 0 0 0 0 0 0 13 0 0 % P
% Gln: 0 0 0 0 0 0 38 0 38 13 0 0 0 0 0 % Q
% Arg: 0 13 0 0 0 38 13 0 0 0 0 38 0 13 0 % R
% Ser: 0 0 0 25 0 25 0 0 25 13 75 0 50 0 0 % S
% Thr: 0 0 0 0 0 25 0 63 0 38 0 13 13 13 13 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 13 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 13 0 0 0 0 0 0 0 0 0 0 0 13 13 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _