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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLKL
All Species:
9.09
Human Site:
T9
Identified Species:
28.57
UniProt:
Q8NB16
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NB16
NP_689862.1
471
54479
T9
E
N
L
K
H
I
I
T
L
G
Q
V
I
H
K
Chimpanzee
Pan troglodytes
XP_001137657
471
54422
T9
E
N
L
K
H
I
I
T
L
G
Q
V
I
H
K
Rhesus Macaque
Macaca mulatta
XP_001108382
470
54717
T9
E
N
L
K
H
I
I
T
L
G
Q
V
I
H
K
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q9D2Y4
472
54299
K9
D
K
L
G
Q
I
I
K
L
G
Q
L
I
Y
E
Rat
Rattus norvegicus
XP_001075467
464
53291
K9
D
K
L
G
Q
I
I
K
L
G
Q
L
I
Y
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512485
545
62578
D9
E
I
L
G
H
I
L
D
L
A
Q
K
I
Y
D
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002314950
781
86168
A20
K
K
I
Q
Q
L
E
A
G
H
H
H
L
Q
Q
Maize
Zea mays
NP_001148926
423
46385
D9
A
Q
G
I
N
F
P
D
F
I
G
A
V
G
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.6
90.4
N.A.
N.A.
61.8
62
N.A.
44.9
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
95.5
N.A.
N.A.
77.5
77.4
N.A.
61.8
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
N.A.
N.A.
46.6
46.6
N.A.
46.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
N.A.
N.A.
73.3
66.6
N.A.
60
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
20.6
23.1
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
34.7
43.1
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
0
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
40
13.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
0
0
0
0
0
0
13
0
13
0
13
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
25
0
0
0
0
0
0
25
0
0
0
0
0
0
25
% D
% Glu:
50
0
0
0
0
0
13
0
0
0
0
0
0
0
13
% E
% Phe:
0
0
0
0
0
13
0
0
13
0
0
0
0
0
0
% F
% Gly:
0
0
13
38
0
0
0
0
13
63
13
0
0
13
13
% G
% His:
0
0
0
0
50
0
0
0
0
13
13
13
0
38
0
% H
% Ile:
0
13
13
13
0
75
63
0
0
13
0
0
75
0
0
% I
% Lys:
13
38
0
38
0
0
0
25
0
0
0
13
0
0
38
% K
% Leu:
0
0
75
0
0
13
13
0
75
0
0
25
13
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
38
0
0
13
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
13
0
0
0
0
0
0
0
0
% P
% Gln:
0
13
0
13
38
0
0
0
0
0
75
0
0
13
13
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
38
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
38
13
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
38
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _