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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK9
All Species:
16.97
Human Site:
S47
Identified Species:
62.22
UniProt:
Q8NBP7
Number Species:
6
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NBP7
NP_777596.2
692
74372
S47
E
L
V
L
A
L
R
S
E
E
D
G
L
A
E
Chimpanzee
Pan troglodytes
A8T644
692
74315
S47
E
L
V
L
A
L
R
S
E
E
D
G
L
A
E
Rhesus Macaque
Macaca mulatta
A8T666
692
74509
S47
E
L
V
L
A
L
R
S
E
E
D
G
L
A
D
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q80W65
694
74805
S50
E
L
M
L
A
L
P
S
Q
E
D
G
L
A
D
Rat
Rattus norvegicus
P59996
691
74690
S46
E
L
M
L
A
L
P
S
Q
E
D
S
L
V
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001088613
676
74160
M38
E
I
V
L
S
F
A
M
Q
E
E
A
Q
V
D
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001190946
626
64435
R30
Q
R
N
R
I
P
G
R
Y
I
V
K
L
K
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
96.3
N.A.
N.A.
76.8
77
N.A.
N.A.
N.A.
59
N.A.
N.A.
N.A.
N.A.
N.A.
26.8
Protein Similarity:
100
99.4
97.5
N.A.
N.A.
83.8
83
N.A.
N.A.
N.A.
74.7
N.A.
N.A.
N.A.
N.A.
N.A.
40.3
P-Site Identity:
100
100
93.3
N.A.
N.A.
73.3
60
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
100
N.A.
N.A.
93.3
80
N.A.
N.A.
N.A.
60
N.A.
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
72
0
15
0
0
0
0
15
0
58
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
72
0
0
0
58
% D
% Glu:
86
0
0
0
0
0
0
0
43
86
15
0
0
0
43
% E
% Phe:
0
0
0
0
0
15
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
15
0
0
0
0
58
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
15
0
0
15
0
0
0
0
15
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
15
0
15
0
% K
% Leu:
0
72
0
86
0
72
0
0
0
0
0
0
86
0
0
% L
% Met:
0
0
29
0
0
0
0
15
0
0
0
0
0
0
0
% M
% Asn:
0
0
15
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
15
29
0
0
0
0
0
0
0
0
% P
% Gln:
15
0
0
0
0
0
0
0
43
0
0
0
15
0
0
% Q
% Arg:
0
15
0
15
0
0
43
15
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
15
0
0
72
0
0
0
15
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
58
0
0
0
0
0
0
0
15
0
0
29
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
15
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _