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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ZNRF1
All Species:
13.64
Human Site:
S154
Identified Species:
27.27
UniProt:
Q8ND25
Number Species:
11
Phosphosite Substitution
Charge Score:
0.45
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8ND25
NP_115644.1
227
23783
S154
I
C
S
K
S
V
A
S
D
E
M
E
M
H
F
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001109563
278
29893
S154
I
C
S
K
S
V
A
S
D
E
M
E
M
H
F
Dog
Lupus familis
XP_854366
187
20677
M117
K
F
V
P
S
D
E
M
D
L
H
L
V
M
C
Cat
Felis silvestris
Mouse
Mus musculus
Q91V17
227
23824
S154
I
C
S
K
S
V
A
S
D
E
M
E
M
H
F
Rat
Rattus norvegicus
XP_002725463
227
23854
S154
I
C
S
K
S
V
A
S
D
E
M
E
M
H
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512110
89
10164
D20
F
V
P
S
D
E
M
D
L
H
L
V
M
C
L
Chicken
Gallus gallus
XP_418778
146
15603
M76
K
F
V
S
S
D
E
M
D
L
H
L
V
M
C
Frog
Xenopus laevis
Q66KG7
195
20714
E124
S
K
S
V
A
S
D
E
M
E
M
H
F
I
M
Zebra Danio
Brachydanio rerio
Q6P4U6
215
22857
E146
S
V
A
S
N
E
M
E
V
H
F
I
M
C
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572359
303
31946
P230
V
C
N
K
F
V
L
P
D
D
I
E
C
H
L
Honey Bee
Apis mellifera
XP_624991
212
22738
E143
F
I
L
P
D
D
I
E
C
H
L
V
M
C
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001198564
213
21441
E144
F
V
G
A
D
N
I
E
L
H
L
L
A
C
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
80.9
44.9
N.A.
99.1
98.6
N.A.
31.2
44.4
72.2
82.8
N.A.
37.6
38.7
N.A.
39.2
Protein Similarity:
100
N.A.
80.9
55.9
N.A.
99.1
98.6
N.A.
35.6
53.7
77.9
88.1
N.A.
47.1
50.2
N.A.
52.8
P-Site Identity:
100
N.A.
100
13.3
N.A.
100
100
N.A.
6.6
13.3
20
6.6
N.A.
40
6.6
N.A.
0
P-Site Similarity:
100
N.A.
100
20
N.A.
100
100
N.A.
13.3
20
26.6
20
N.A.
66.6
13.3
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
9
9
0
34
0
0
0
0
0
9
0
0
% A
% Cys:
0
42
0
0
0
0
0
0
9
0
0
0
9
34
17
% C
% Asp:
0
0
0
0
25
25
9
9
59
9
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
17
17
34
0
42
0
42
0
0
0
% E
% Phe:
25
17
0
0
9
0
0
0
0
0
9
0
9
0
34
% F
% Gly:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
34
17
9
0
42
0
% H
% Ile:
34
9
0
0
0
0
17
0
0
0
9
9
0
9
0
% I
% Lys:
17
9
0
42
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
9
0
0
0
9
0
17
17
25
25
0
0
42
% L
% Met:
0
0
0
0
0
0
17
17
9
0
42
0
59
17
9
% M
% Asn:
0
0
9
0
9
9
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
9
17
0
0
0
9
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
17
0
42
25
50
9
0
34
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
9
25
17
9
0
42
0
0
9
0
0
17
17
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _