KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPEPL1
All Species:
5.15
Human Site:
T222
Identified Species:
8.72
UniProt:
Q8NDH3
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NDH3
NP_078939.3
523
55861
T222
I
R
D
E
E
L
K
T
R
G
F
G
G
I
Y
Chimpanzee
Pan troglodytes
XP_525369
359
37700
Q106
H
T
P
D
G
A
T
Q
T
I
A
W
V
G
K
Rhesus Macaque
Macaca mulatta
XP_001086311
463
49382
A206
G
I
Y
G
V
G
K
A
A
L
H
P
P
A
L
Dog
Lupus familis
XP_543071
397
42215
S144
R
S
G
A
S
R
R
S
E
K
K
T
V
T
V
Cat
Felis silvestris
Mouse
Mus musculus
Q6NSR8
524
55922
T222
I
R
D
E
Q
L
K
T
K
G
F
G
G
I
Y
Rat
Rattus norvegicus
NP_001101276
412
43664
I159
Y
D
T
G
G
L
S
I
K
G
K
T
T
M
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511141
548
58651
K247
I
R
D
E
E
L
K
K
R
G
F
G
G
I
Y
Chicken
Gallus gallus
XP_417486
523
56072
E222
I
R
D
E
E
L
K
E
R
G
F
G
G
I
Y
Frog
Xenopus laevis
NP_001090314
521
55831
Q222
I
R
D
V
E
L
K
Q
R
G
F
G
G
I
Y
Zebra Danio
Brachydanio rerio
NP_001017688
525
55746
Q222
I
R
G
E
E
L
K
Q
K
G
F
G
G
I
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650240
558
60151
E266
I
R
G
E
E
L
L
E
Q
G
F
G
G
I
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34629
491
52431
K214
I
R
G
E
E
L
L
K
A
G
F
G
G
I
Y
Sea Urchin
Strong. purpuratus
XP_780549
523
55941
Q224
I
Q
G
E
E
L
K
Q
K
G
F
G
G
I
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001151608
535
57316
E237
V
L
G
E
E
L
K
E
K
G
F
G
G
I
Y
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.3
84.6
72
N.A.
94.6
74.3
N.A.
83.9
87.7
83.5
81.1
N.A.
58.4
N.A.
42.6
58.7
Protein Similarity:
100
67.8
85.8
74.1
N.A.
97.3
77
N.A.
89.2
94.4
92.1
90
N.A.
72.2
N.A.
56.5
74.9
P-Site Identity:
100
0
6.6
0
N.A.
86.6
13.3
N.A.
93.3
93.3
86.6
80
N.A.
73.3
N.A.
73.3
73.3
P-Site Similarity:
100
6.6
6.6
13.3
N.A.
100
26.6
N.A.
93.3
93.3
86.6
86.6
N.A.
80
N.A.
73.3
86.6
Percent
Protein Identity:
N.A.
58.5
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
74.7
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
66.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
80
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
8
0
8
15
0
8
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
36
8
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
65
65
0
0
22
8
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
72
0
0
0
0
% F
% Gly:
8
0
43
15
15
8
0
0
0
79
0
72
72
8
0
% G
% His:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
65
8
0
0
0
0
0
8
0
8
0
0
0
72
0
% I
% Lys:
0
0
0
0
0
0
65
15
36
8
15
0
0
0
8
% K
% Leu:
0
8
0
0
0
79
15
0
0
8
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
8
0
0
0
0
0
0
0
0
8
8
0
8
% P
% Gln:
0
8
0
0
8
0
0
29
8
0
0
0
0
0
0
% Q
% Arg:
8
58
0
0
0
8
8
0
29
0
0
0
0
0
0
% R
% Ser:
0
8
0
0
8
0
8
8
0
0
0
0
0
0
0
% S
% Thr:
0
8
8
0
0
0
8
15
8
0
0
15
8
8
0
% T
% Val:
8
0
0
8
8
0
0
0
0
0
0
0
15
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
72
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _