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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMEM104
All Species:
19.09
Human Site:
S177
Identified Species:
35
UniProt:
Q8NE00
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NE00
NP_060198.3
496
55679
S177
S
L
M
Q
V
T
C
S
A
T
G
N
D
S
C
Chimpanzee
Pan troglodytes
XP_523714
496
55145
S177
S
L
M
Q
V
T
C
S
A
T
G
N
D
S
C
Rhesus Macaque
Macaca mulatta
XP_001089622
496
55721
S177
S
L
M
Q
V
T
C
S
A
A
G
N
D
S
C
Dog
Lupus familis
XP_540420
495
55718
A177
S
L
M
Q
V
T
C
A
T
G
N
E
S
C
G
Cat
Felis silvestris
Mouse
Mus musculus
Q3TB48
496
55820
S177
S
L
M
Q
V
T
C
S
V
S
G
N
D
S
C
Rat
Rattus norvegicus
XP_221104
496
55610
S177
S
L
M
Q
V
T
C
S
V
S
G
N
D
S
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513737
503
55788
A181
S
L
M
Q
V
T
C
A
G
A
A
D
G
G
N
Chicken
Gallus gallus
Q5F3I6
497
56100
A179
S
L
M
Q
V
T
C
A
I
G
N
H
S
C
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_693756
493
55194
G177
S
L
M
E
V
A
C
G
N
H
S
C
S
A
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VPF8
509
57548
D183
S
L
R
D
V
V
C
D
Q
T
N
G
T
D
T
Honey Bee
Apis mellifera
XP_624947
517
58006
T188
T
L
A
D
V
I
C
T
Y
Q
P
T
N
F
T
Nematode Worm
Caenorhab. elegans
Q17598
492
54003
F182
Y
R
F
F
V
I
I
F
V
V
V
V
C
L
P
Sea Urchin
Strong. purpuratus
XP_780904
427
48681
A136
A
D
I
S
R
M
N
A
Y
R
I
Y
L
S
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.5
98.5
92.7
N.A.
89.7
89.1
N.A.
80.7
81.8
N.A.
73.9
N.A.
43
47
38.3
43.5
Protein Similarity:
100
92.5
99.4
96.1
N.A.
94.1
93.9
N.A.
88.6
90.5
N.A.
82.6
N.A.
64.8
64.9
57.8
59.6
P-Site Identity:
100
100
93.3
46.6
N.A.
86.6
86.6
N.A.
46.6
46.6
N.A.
33.3
N.A.
33.3
20
6.6
6.6
P-Site Similarity:
100
100
93.3
53.3
N.A.
93.3
93.3
N.A.
60
60
N.A.
46.6
N.A.
33.3
40
6.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
0
8
0
31
24
16
8
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
85
0
0
0
0
8
8
16
39
% C
% Asp:
0
8
0
16
0
0
0
8
0
0
0
8
39
8
0
% D
% Glu:
0
0
0
8
0
0
0
0
0
0
0
8
0
0
0
% E
% Phe:
0
0
8
8
0
0
0
8
0
0
0
0
0
8
0
% F
% Gly:
0
0
0
0
0
0
0
8
8
16
39
8
8
8
16
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
0
% H
% Ile:
0
0
8
0
0
16
8
0
8
0
8
0
0
0
8
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
85
0
0
0
0
0
0
0
0
0
0
8
8
0
% L
% Met:
0
0
70
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
8
0
24
39
8
0
16
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
8
% P
% Gln:
0
0
0
62
0
0
0
0
8
8
0
0
0
0
0
% Q
% Arg:
0
8
8
0
8
0
0
0
0
8
0
0
0
0
0
% R
% Ser:
77
0
0
8
0
0
0
39
0
16
8
0
24
47
0
% S
% Thr:
8
0
0
0
0
62
0
8
8
24
0
8
8
0
16
% T
% Val:
0
0
0
0
93
8
0
0
24
8
8
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
16
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _