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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMEM104
All Species:
31.82
Human Site:
T127
Identified Species:
58.33
UniProt:
Q8NE00
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NE00
NP_060198.3
496
55679
T127
S
P
N
P
F
E
I
T
D
R
V
E
M
G
Q
Chimpanzee
Pan troglodytes
XP_523714
496
55145
T127
S
P
N
P
F
E
I
T
D
R
V
E
M
G
Q
Rhesus Macaque
Macaca mulatta
XP_001089622
496
55721
T127
S
P
N
P
F
E
I
T
D
R
V
E
M
G
Q
Dog
Lupus familis
XP_540420
495
55718
T127
S
L
N
L
F
E
I
T
D
R
V
E
M
G
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q3TB48
496
55820
T127
S
A
N
L
F
E
I
T
D
R
V
E
M
G
Q
Rat
Rattus norvegicus
XP_221104
496
55610
T127
S
A
S
L
F
E
I
T
E
R
V
E
M
G
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513737
503
55788
T131
P
P
C
V
F
E
I
T
D
R
I
E
M
G
Q
Chicken
Gallus gallus
Q5F3I6
497
56100
T129
S
P
N
I
F
E
I
T
E
R
V
E
M
G
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_693756
493
55194
V127
N
I
D
H
F
D
I
V
E
R
V
E
M
G
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VPF8
509
57548
S133
E
F
H
Y
Y
Q
L
S
H
K
F
E
L
G
E
Honey Bee
Apis mellifera
XP_624947
517
58006
R138
T
Y
R
Y
Y
I
I
R
D
K
I
E
M
G
Q
Nematode Worm
Caenorhab. elegans
Q17598
492
54003
A132
I
Y
L
F
G
D
L
A
I
Y
S
T
T
V
P
Sea Urchin
Strong. purpuratus
XP_780904
427
48681
L86
Q
I
L
F
Y
I
C
L
I
V
Y
L
Y
G
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.5
98.5
92.7
N.A.
89.7
89.1
N.A.
80.7
81.8
N.A.
73.9
N.A.
43
47
38.3
43.5
Protein Similarity:
100
92.5
99.4
96.1
N.A.
94.1
93.9
N.A.
88.6
90.5
N.A.
82.6
N.A.
64.8
64.9
57.8
59.6
P-Site Identity:
100
100
100
86.6
N.A.
86.6
73.3
N.A.
73.3
86.6
N.A.
53.3
N.A.
13.3
40
0
6.6
P-Site Similarity:
100
100
100
86.6
N.A.
86.6
86.6
N.A.
80
93.3
N.A.
80
N.A.
66.6
66.6
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
0
0
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
8
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
16
0
0
54
0
0
0
0
0
8
% D
% Glu:
8
0
0
0
0
62
0
0
24
0
0
85
0
0
8
% E
% Phe:
0
8
0
16
70
0
0
0
0
0
8
0
0
0
0
% F
% Gly:
0
0
0
0
8
0
0
0
0
0
0
0
0
93
0
% G
% His:
0
0
8
8
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
8
16
0
8
0
16
77
0
16
0
16
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
16
0
0
0
0
0
% K
% Leu:
0
8
16
24
0
0
16
8
0
0
0
8
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
77
0
0
% M
% Asn:
8
0
47
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
8
39
0
24
0
0
0
0
0
0
0
0
0
0
8
% P
% Gln:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
77
% Q
% Arg:
0
0
8
0
0
0
0
8
0
70
0
0
0
0
0
% R
% Ser:
54
0
8
0
0
0
0
8
0
0
8
0
0
0
0
% S
% Thr:
8
0
0
0
0
0
0
62
0
0
0
8
8
0
0
% T
% Val:
0
0
0
8
0
0
0
8
0
8
62
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
16
0
16
24
0
0
0
0
8
8
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _