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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMEM104
All Species:
35.76
Human Site:
T295
Identified Species:
65.56
UniProt:
Q8NE00
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NE00
NP_060198.3
496
55679
T295
H
S
L
P
S
L
I
T
P
V
S
S
K
R
H
Chimpanzee
Pan troglodytes
XP_523714
496
55145
T295
H
S
L
P
S
L
I
T
P
V
S
S
K
R
H
Rhesus Macaque
Macaca mulatta
XP_001089622
496
55721
T295
H
S
L
P
S
L
I
T
P
V
S
S
K
R
H
Dog
Lupus familis
XP_540420
495
55718
T294
H
S
L
P
S
L
I
T
P
V
S
S
K
R
H
Cat
Felis silvestris
Mouse
Mus musculus
Q3TB48
496
55820
T295
H
S
L
P
S
L
I
T
P
I
S
S
K
R
H
Rat
Rattus norvegicus
XP_221104
496
55610
T295
H
S
L
P
S
L
I
T
P
I
S
S
K
R
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513737
503
55788
T302
H
S
L
P
S
L
I
T
P
I
S
S
K
R
H
Chicken
Gallus gallus
Q5F3I6
497
56100
T296
H
S
L
P
S
L
I
T
P
I
S
K
K
R
H
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_693756
493
55194
T291
H
S
L
P
S
L
V
T
P
I
S
N
K
Q
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VPF8
509
57548
A307
H
S
L
P
S
L
L
A
P
I
R
H
K
S
M
Honey Bee
Apis mellifera
XP_624947
517
58006
A305
H
S
L
P
A
L
V
A
P
I
A
N
K
T
T
Nematode Worm
Caenorhab. elegans
Q17598
492
54003
V300
G
A
F
A
F
E
H
V
Q
D
I
Y
T
L
N
Sea Urchin
Strong. purpuratus
XP_780904
427
48681
F236
P
K
K
R
I
T
A
F
L
F
G
D
Y
I
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.5
98.5
92.7
N.A.
89.7
89.1
N.A.
80.7
81.8
N.A.
73.9
N.A.
43
47
38.3
43.5
Protein Similarity:
100
92.5
99.4
96.1
N.A.
94.1
93.9
N.A.
88.6
90.5
N.A.
82.6
N.A.
64.8
64.9
57.8
59.6
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
93.3
86.6
N.A.
66.6
N.A.
53.3
46.6
0
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
93.3
N.A.
93.3
N.A.
66.6
80
13.3
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
8
0
8
16
0
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
0
% D
% Glu:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
8
0
8
0
0
8
0
8
0
0
0
0
0
% F
% Gly:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% G
% His:
85
0
0
0
0
0
8
0
0
0
0
8
0
0
62
% H
% Ile:
0
0
0
0
8
0
62
0
0
54
8
0
0
8
0
% I
% Lys:
0
8
8
0
0
0
0
0
0
0
0
8
85
0
0
% K
% Leu:
0
0
85
0
0
85
8
0
8
0
0
0
0
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
16
0
0
8
% N
% Pro:
8
0
0
85
0
0
0
0
85
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% Q
% Arg:
0
0
0
8
0
0
0
0
0
0
8
0
0
62
8
% R
% Ser:
0
85
0
0
77
0
0
0
0
0
70
54
0
8
0
% S
% Thr:
0
0
0
0
0
8
0
70
0
0
0
0
8
8
8
% T
% Val:
0
0
0
0
0
0
16
8
0
31
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _