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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMEM104
All Species:
30
Human Site:
Y104
Identified Species:
55
UniProt:
Q8NE00
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NE00
NP_060198.3
496
55679
Y104
D
V
L
I
R
D
N
Y
E
R
A
E
K
R
P
Chimpanzee
Pan troglodytes
XP_523714
496
55145
Y104
D
V
L
I
R
D
N
Y
E
R
A
E
K
R
P
Rhesus Macaque
Macaca mulatta
XP_001089622
496
55721
Y104
D
V
L
I
R
D
N
Y
E
R
A
E
K
R
P
Dog
Lupus familis
XP_540420
495
55718
Y104
D
V
L
V
Q
D
N
Y
E
R
A
E
K
R
P
Cat
Felis silvestris
Mouse
Mus musculus
Q3TB48
496
55820
Y104
D
L
L
S
Q
D
N
Y
E
R
A
E
K
R
P
Rat
Rattus norvegicus
XP_221104
496
55610
Y104
D
L
L
S
Q
D
N
Y
E
R
A
E
K
R
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513737
503
55788
F108
D
P
L
V
P
G
S
F
D
R
S
E
T
R
P
Chicken
Gallus gallus
Q5F3I6
497
56100
Y106
D
V
L
L
R
D
S
Y
E
R
A
E
T
R
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_693756
493
55194
S104
E
V
I
I
R
G
R
S
E
P
V
E
T
R
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VPF8
509
57548
E110
V
S
L
A
S
G
A
E
Q
V
G
D
F
E
R
Honey Bee
Apis mellifera
XP_624947
517
58006
T115
S
N
L
D
S
E
D
T
P
L
V
T
P
F
S
Nematode Worm
Caenorhab. elegans
Q17598
492
54003
M109
E
V
S
E
M
A
S
M
F
L
S
K
V
S
L
Sea Urchin
Strong. purpuratus
XP_780904
427
48681
L63
D
Y
F
E
I
T
E
L
V
D
M
G
Q
M
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.5
98.5
92.7
N.A.
89.7
89.1
N.A.
80.7
81.8
N.A.
73.9
N.A.
43
47
38.3
43.5
Protein Similarity:
100
92.5
99.4
96.1
N.A.
94.1
93.9
N.A.
88.6
90.5
N.A.
82.6
N.A.
64.8
64.9
57.8
59.6
P-Site Identity:
100
100
100
86.6
N.A.
80
80
N.A.
40
80
N.A.
46.6
N.A.
6.6
6.6
6.6
6.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
73.3
93.3
N.A.
60
N.A.
20
20
33.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
8
8
0
0
0
54
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
70
0
0
8
0
54
8
0
8
8
0
8
0
0
0
% D
% Glu:
16
0
0
16
0
8
8
8
62
0
0
70
0
8
0
% E
% Phe:
0
0
8
0
0
0
0
8
8
0
0
0
8
8
0
% F
% Gly:
0
0
0
0
0
24
0
0
0
0
8
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
31
8
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
8
47
0
0
% K
% Leu:
0
16
77
8
0
0
0
8
0
16
0
0
0
0
8
% L
% Met:
0
0
0
0
8
0
0
8
0
0
8
0
0
8
0
% M
% Asn:
0
8
0
0
0
0
47
0
0
0
0
0
0
0
0
% N
% Pro:
0
8
0
0
8
0
0
0
8
8
0
0
8
0
70
% P
% Gln:
0
0
0
0
24
0
0
0
8
0
0
0
8
0
0
% Q
% Arg:
0
0
0
0
39
0
8
0
0
62
0
0
0
70
8
% R
% Ser:
8
8
8
16
16
0
24
8
0
0
16
0
0
8
8
% S
% Thr:
0
0
0
0
0
8
0
8
0
0
0
8
24
0
0
% T
% Val:
8
54
0
16
0
0
0
0
8
8
16
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
54
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _