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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMEM104
All Species:
19.7
Human Site:
Y232
Identified Species:
36.11
UniProt:
Q8NE00
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NE00
NP_060198.3
496
55679
Y232
F
D
V
Q
K
T
K
Y
L
Q
I
L
T
S
L
Chimpanzee
Pan troglodytes
XP_523714
496
55145
Y232
F
D
V
Q
K
T
K
Y
L
Q
I
L
T
S
L
Rhesus Macaque
Macaca mulatta
XP_001089622
496
55721
Y232
F
D
V
Q
K
T
K
Y
L
Q
I
L
T
S
L
Dog
Lupus familis
XP_540420
495
55718
L232
D
V
Q
K
T
K
Y
L
Q
I
L
T
S
L
M
Cat
Felis silvestris
Mouse
Mus musculus
Q3TB48
496
55820
Y232
F
D
V
Q
K
T
K
Y
L
Q
I
L
T
S
M
Rat
Rattus norvegicus
XP_221104
496
55610
Y232
F
D
V
Q
K
T
K
Y
L
Q
I
L
T
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513737
503
55788
K236
F
T
F
F
N
V
Q
K
T
K
Y
L
Q
I
V
Chicken
Gallus gallus
Q5F3I6
497
56100
L234
N
V
Q
K
T
K
Y
L
Q
I
M
T
S
L
M
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_693756
493
55194
L232
K
T
K
Y
L
Q
I
L
T
S
L
M
R
W
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VPF8
509
57548
N238
F
G
P
F
V
Y
F
N
V
Q
K
T
K
Y
L
Honey Bee
Apis mellifera
XP_624947
517
58006
L243
N
I
Q
K
T
K
Y
L
Q
L
L
T
S
A
M
Nematode Worm
Caenorhab. elegans
Q17598
492
54003
N237
A
A
H
P
P
A
Y
N
F
H
G
F
G
S
L
Sea Urchin
Strong. purpuratus
XP_780904
427
48681
S191
Y
I
S
Q
G
K
S
S
I
K
P
A
A
T
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.5
98.5
92.7
N.A.
89.7
89.1
N.A.
80.7
81.8
N.A.
73.9
N.A.
43
47
38.3
43.5
Protein Similarity:
100
92.5
99.4
96.1
N.A.
94.1
93.9
N.A.
88.6
90.5
N.A.
82.6
N.A.
64.8
64.9
57.8
59.6
P-Site Identity:
100
100
100
0
N.A.
93.3
100
N.A.
13.3
0
N.A.
0
N.A.
20
0
13.3
6.6
P-Site Similarity:
100
100
100
26.6
N.A.
100
100
N.A.
33.3
26.6
N.A.
20
N.A.
26.6
33.3
13.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
0
0
8
0
0
0
0
0
8
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
39
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
54
0
8
16
0
0
8
0
8
0
0
8
0
0
0
% F
% Gly:
0
8
0
0
8
0
0
0
0
0
8
0
8
0
8
% G
% His:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
16
0
0
0
0
8
0
8
16
39
0
0
8
8
% I
% Lys:
8
0
8
24
39
31
39
8
0
16
8
0
8
0
0
% K
% Leu:
0
0
0
0
8
0
0
31
39
8
24
47
0
16
47
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
8
0
0
31
% M
% Asn:
16
0
0
0
8
0
0
16
0
0
0
0
0
0
0
% N
% Pro:
0
0
8
8
8
0
0
0
0
0
8
0
0
0
0
% P
% Gln:
0
0
24
47
0
8
8
0
24
47
0
0
8
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% R
% Ser:
0
0
8
0
0
0
8
8
0
8
0
0
24
47
0
% S
% Thr:
0
16
0
0
24
39
0
0
16
0
0
31
39
8
0
% T
% Val:
0
16
39
0
8
8
0
0
8
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
8
0
0
8
0
8
31
39
0
0
8
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _