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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPAPDC1B All Species: 28.18
Human Site: S45 Identified Species: 44.29
UniProt: Q8NEB5 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8NEB5 NP_001096029.1 223 25159 S45 K K A D T R D S R Q A C L A A
Chimpanzee Pan troglodytes XP_001170623 223 25141 S45 K K A D T R D S R Q A C L A A
Rhesus Macaque Macaca mulatta XP_001092746 343 37863 S164 K K A D T R D S R Q A C L A A
Dog Lupus familis XP_532804 262 29068 S84 R K A G P T D S R Q A C L A A
Cat Felis silvestris
Mouse Mus musculus Q3UMZ3 260 29204 S82 R K A D A T D S K Q A C L A A
Rat Rattus norvegicus O08564 282 31978 F105 I Y K A V G A F L F G A S A S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506195 245 27549 T60 K K A D R T D T K Q A C L A A
Chicken Gallus gallus XP_001234075 241 26848 T60 L G A D H E D T R E A S L A A
Frog Xenopus laevis Q6GQ62 226 25153 S45 W K A D G T D S R E A G L A A
Zebra Danio Brachydanio rerio XP_001921179 256 28767 I61 Q R T D R T E I K E A C L A V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623887 268 30640 I87 V Y K D K T D I Y Q A I L A V
Nematode Worm Caenorhab. elegans Q10022 341 39009 Y128 R L L T Y F G Y S Q I G F V M
Sea Urchin Strong. purpuratus XP_787511 258 29394 S67 L C V I T I F S L M R K D R L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8LFD1 364 40756 H148 R D V Y D L H H A V L G L L Y
Baker's Yeast Sacchar. cerevisiae Q05521 289 33495 L101 F I L Y T S L L G L S L A W F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 100 63.8 74.4 N.A. 76.5 20.2 N.A. 68.5 64.3 64.5 51.5 N.A. N.A. 41.7 22.5 37.9
Protein Similarity: 100 100 64.1 78.2 N.A. 80 35.4 N.A. 77.5 72.1 77.8 67.5 N.A. N.A. 53.7 36.3 51.9
P-Site Identity: 100 100 100 73.3 N.A. 73.3 6.6 N.A. 73.3 53.3 66.6 33.3 N.A. N.A. 40 6.6 13.3
P-Site Similarity: 100 100 100 80 N.A. 86.6 13.3 N.A. 86.6 66.6 73.3 66.6 N.A. N.A. 40 13.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. 28.5 31.8 N.A.
Protein Similarity: N.A. N.A. N.A. 40.1 48.4 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 54 7 7 0 7 0 7 0 67 7 7 74 54 % A
% Cys: 0 7 0 0 0 0 0 0 0 0 0 47 0 0 0 % C
% Asp: 0 7 0 60 7 0 60 0 0 0 0 0 7 0 0 % D
% Glu: 0 0 0 0 0 7 7 0 0 20 0 0 0 0 0 % E
% Phe: 7 0 0 0 0 7 7 7 0 7 0 0 7 0 7 % F
% Gly: 0 7 0 7 7 7 7 0 7 0 7 20 0 0 0 % G
% His: 0 0 0 0 7 0 7 7 0 0 0 0 0 0 0 % H
% Ile: 7 7 0 7 0 7 0 14 0 0 7 7 0 0 0 % I
% Lys: 27 47 14 0 7 0 0 0 20 0 0 7 0 0 0 % K
% Leu: 14 7 14 0 0 7 7 7 14 7 7 7 74 7 7 % L
% Met: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 7 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 7 0 0 0 0 0 0 0 0 54 0 0 0 0 0 % Q
% Arg: 27 7 0 0 14 20 0 0 40 0 7 0 0 7 0 % R
% Ser: 0 0 0 0 0 7 0 47 7 0 7 7 7 0 7 % S
% Thr: 0 0 7 7 34 40 0 14 0 0 0 0 0 0 0 % T
% Val: 7 0 14 0 7 0 0 0 0 7 0 0 0 7 14 % V
% Trp: 7 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % W
% Tyr: 0 14 0 14 7 0 0 7 7 0 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _