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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3C3
All Species:
26.67
Human Site:
S173
Identified Species:
53.33
UniProt:
Q8NEB9
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NEB9
NP_002638.2
887
101549
S173
T
L
S
E
D
Q
M
S
R
L
A
K
L
T
K
Chimpanzee
Pan troglodytes
XP_001142269
757
86303
A104
Y
P
D
L
P
R
N
A
Q
V
A
L
T
I
W
Rhesus Macaque
Macaca mulatta
XP_001082892
887
101541
S173
T
L
S
E
D
Q
M
S
R
L
A
K
L
T
K
Dog
Lupus familis
XP_547599
1258
142817
S477
T
L
S
E
D
Q
M
S
R
L
A
K
L
T
K
Cat
Felis silvestris
Mouse
Mus musculus
Q6PF93
887
101469
S173
T
L
S
E
D
Q
M
S
R
L
A
K
L
T
K
Rat
Rattus norvegicus
O88763
887
101516
S173
T
L
S
E
D
Q
M
S
R
L
A
K
L
T
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6AZN6
886
101139
S173
S
A
S
E
D
Q
M
S
R
L
A
K
L
T
K
Zebra Danio
Brachydanio rerio
NP_001017550
726
82679
V73
G
K
P
L
A
L
P
V
R
T
S
Y
K
A
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477133
949
107871
G176
K
S
Q
M
Q
R
L
G
K
L
A
K
K
H
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
Y192
D
I
S
H
C
L
G
Y
S
L
D
K
L
E
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
R161
G
K
V
P
R
H
E
R
G
E
L
E
R
L
E
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
S186
W
L
D
E
I
T
I
S
K
L
R
K
Q
R
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.1
99.5
69.7
N.A.
97.9
98
N.A.
N.A.
N.A.
92
69.7
N.A.
55.9
N.A.
20
N.A.
Protein Similarity:
100
85.3
99.8
69.9
N.A.
98.9
99.4
N.A.
N.A.
N.A.
96.2
76.4
N.A.
71.9
N.A.
37.9
N.A.
P-Site Identity:
100
6.6
100
100
N.A.
100
100
N.A.
N.A.
N.A.
86.6
6.6
N.A.
20
N.A.
26.6
N.A.
P-Site Similarity:
100
33.3
100
100
N.A.
100
100
N.A.
N.A.
N.A.
93.3
13.3
N.A.
46.6
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.8
36.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
60.4
55.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
9
0
0
9
0
0
67
0
0
9
0
% A
% Cys:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
17
0
50
0
0
0
0
0
9
0
0
0
0
% D
% Glu:
0
0
0
59
0
0
9
0
0
9
0
9
0
9
25
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% F
% Gly:
17
0
0
0
0
0
9
9
9
0
0
0
0
0
0
% G
% His:
0
0
0
9
0
9
0
0
0
0
0
0
0
9
0
% H
% Ile:
0
9
0
0
9
0
9
0
0
0
0
0
0
9
0
% I
% Lys:
9
17
0
0
0
0
0
0
17
0
0
75
17
0
50
% K
% Leu:
0
50
0
17
0
17
9
0
0
75
9
9
59
9
0
% L
% Met:
0
0
0
9
0
0
50
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% N
% Pro:
0
9
9
9
9
0
9
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
9
0
9
50
0
0
9
0
0
0
9
0
0
% Q
% Arg:
0
0
0
0
9
17
0
9
59
0
9
0
9
9
9
% R
% Ser:
9
9
59
0
0
0
0
59
9
0
9
0
0
0
0
% S
% Thr:
42
0
0
0
0
9
0
0
0
9
0
0
9
50
0
% T
% Val:
0
0
9
0
0
0
0
9
0
9
0
0
0
0
0
% V
% Trp:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% W
% Tyr:
9
0
0
0
0
0
0
9
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _