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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3C3
All Species:
29.7
Human Site:
S25
Identified Species:
59.39
UniProt:
Q8NEB9
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NEB9
NP_002638.2
887
101549
S25
N
V
Q
L
K
I
G
S
L
E
G
K
R
E
Q
Chimpanzee
Pan troglodytes
XP_001142269
757
86303
Rhesus Macaque
Macaca mulatta
XP_001082892
887
101541
S25
N
V
Q
L
K
I
G
S
L
E
G
K
R
E
Q
Dog
Lupus familis
XP_547599
1258
142817
S329
N
V
Q
L
K
I
G
S
L
E
G
K
R
E
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q6PF93
887
101469
S25
N
V
Q
L
K
I
G
S
L
E
G
K
R
E
Q
Rat
Rattus norvegicus
O88763
887
101516
S25
N
V
Q
L
K
I
G
S
L
E
G
K
R
E
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6AZN6
886
101139
S25
S
V
R
L
K
I
G
S
L
E
G
K
R
E
Q
Zebra Danio
Brachydanio rerio
NP_001017550
726
82679
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477133
949
107871
T26
R
V
Q
I
K
V
G
T
L
E
G
K
K
R
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
A25
H
G
A
R
D
L
I
A
G
H
G
R
N
S
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
F20
D
I
N
S
P
V
T
F
R
I
E
K
L
D
G
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
S24
P
L
K
V
K
I
K
S
L
E
G
H
K
P
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.1
99.5
69.7
N.A.
97.9
98
N.A.
N.A.
N.A.
92
69.7
N.A.
55.9
N.A.
20
N.A.
Protein Similarity:
100
85.3
99.8
69.9
N.A.
98.9
99.4
N.A.
N.A.
N.A.
96.2
76.4
N.A.
71.9
N.A.
37.9
N.A.
P-Site Identity:
100
0
100
100
N.A.
100
100
N.A.
N.A.
N.A.
86.6
0
N.A.
60
N.A.
6.6
N.A.
P-Site Similarity:
100
0
100
100
N.A.
100
100
N.A.
N.A.
N.A.
100
0
N.A.
86.6
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.8
36.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
60.4
55.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
0
0
0
9
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
9
0
0
0
0
0
0
0
0
9
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
67
9
0
0
50
0
% E
% Phe:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% F
% Gly:
0
9
0
0
0
0
59
0
9
0
75
0
0
0
9
% G
% His:
9
0
0
0
0
0
0
0
0
9
0
9
0
0
0
% H
% Ile:
0
9
0
9
0
59
9
0
0
9
0
0
0
0
0
% I
% Lys:
0
0
9
0
67
0
9
0
0
0
0
67
17
0
0
% K
% Leu:
0
9
0
50
0
9
0
0
67
0
0
0
9
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
42
0
9
0
0
0
0
0
0
0
0
0
9
0
0
% N
% Pro:
9
0
0
0
9
0
0
0
0
0
0
0
0
9
0
% P
% Gln:
0
0
50
0
0
0
0
0
0
0
0
0
0
0
59
% Q
% Arg:
9
0
9
9
0
0
0
0
9
0
0
9
50
9
9
% R
% Ser:
9
0
0
9
0
0
0
59
0
0
0
0
0
9
0
% S
% Thr:
0
0
0
0
0
0
9
9
0
0
0
0
0
0
0
% T
% Val:
0
59
0
9
0
17
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _