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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3C3
All Species:
18.48
Human Site:
S431
Identified Species:
36.97
UniProt:
Q8NEB9
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NEB9
NP_002638.2
887
101549
S431
S
S
V
S
E
N
V
S
N
S
G
I
N
S
A
Chimpanzee
Pan troglodytes
XP_001142269
757
86303
L341
L
K
C
V
N
W
D
L
P
Q
E
A
K
Q
A
Rhesus Macaque
Macaca mulatta
XP_001082892
887
101541
S431
S
S
V
S
E
N
L
S
N
S
G
I
N
S
A
Dog
Lupus familis
XP_547599
1258
142817
S735
G
S
V
S
E
S
V
S
N
S
G
I
N
S
T
Cat
Felis silvestris
Mouse
Mus musculus
Q6PF93
887
101469
S431
T
S
A
S
E
S
L
S
N
S
G
V
S
S
G
Rat
Rattus norvegicus
O88763
887
101516
S431
A
S
V
S
E
S
L
S
S
S
G
V
S
S
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6AZN6
886
101139
M430
Q
G
P
M
L
E
S
M
T
T
S
G
I
N
P
Zebra Danio
Brachydanio rerio
NP_001017550
726
82679
E310
P
T
K
Q
L
S
S
E
E
Q
D
L
V
W
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477133
949
107871
G489
A
G
G
S
G
S
G
G
Q
G
S
V
A
L
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
R530
T
D
W
R
D
E
L
R
Q
G
Q
F
L
F
H
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
R398
V
Q
A
L
R
F
E
R
S
D
R
S
C
L
S
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
S426
L
S
T
F
S
D
K
S
N
S
E
F
T
I
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.1
99.5
69.7
N.A.
97.9
98
N.A.
N.A.
N.A.
92
69.7
N.A.
55.9
N.A.
20
N.A.
Protein Similarity:
100
85.3
99.8
69.9
N.A.
98.9
99.4
N.A.
N.A.
N.A.
96.2
76.4
N.A.
71.9
N.A.
37.9
N.A.
P-Site Identity:
100
6.6
93.3
80
N.A.
53.3
60
N.A.
N.A.
N.A.
0
0
N.A.
6.6
N.A.
0
N.A.
P-Site Similarity:
100
6.6
100
86.6
N.A.
86.6
100
N.A.
N.A.
N.A.
13.3
20
N.A.
26.6
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.8
36.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
60.4
55.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
0
17
0
0
0
0
0
0
0
0
9
9
0
34
% A
% Cys:
0
0
9
0
0
0
0
0
0
0
0
0
9
0
0
% C
% Asp:
0
9
0
0
9
9
9
0
0
9
9
0
0
0
0
% D
% Glu:
0
0
0
0
42
17
9
9
9
0
17
0
0
0
0
% E
% Phe:
0
0
0
9
0
9
0
0
0
0
0
17
0
9
0
% F
% Gly:
9
17
9
0
9
0
9
9
0
17
42
9
0
0
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
25
9
9
0
% I
% Lys:
0
9
9
0
0
0
9
0
0
0
0
0
9
0
9
% K
% Leu:
17
0
0
9
17
0
34
9
0
0
0
9
9
17
0
% L
% Met:
0
0
0
9
0
0
0
9
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
9
17
0
0
42
0
0
0
25
9
0
% N
% Pro:
9
0
9
0
0
0
0
0
9
0
0
0
0
0
17
% P
% Gln:
9
9
0
9
0
0
0
0
17
17
9
0
0
9
0
% Q
% Arg:
0
0
0
9
9
0
0
17
0
0
9
0
0
0
0
% R
% Ser:
17
50
0
50
9
42
17
50
17
50
17
9
17
42
9
% S
% Thr:
17
9
9
0
0
0
0
0
9
9
0
0
9
0
9
% T
% Val:
9
0
34
9
0
0
17
0
0
0
0
25
9
0
9
% V
% Trp:
0
0
9
0
0
9
0
0
0
0
0
0
0
9
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _