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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3C3
All Species:
0
Human Site:
S452
Identified Species:
0
UniProt:
Q8NEB9
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NEB9
NP_002638.2
887
101549
S452
I
I
T
S
P
L
P
S
V
S
S
P
P
P
A
Chimpanzee
Pan troglodytes
XP_001142269
757
86303
D362
W
K
P
M
D
V
E
D
S
L
E
L
L
S
S
Rhesus Macaque
Macaca mulatta
XP_001082892
887
101541
P452
I
I
T
S
P
L
P
P
V
S
S
P
P
P
A
Dog
Lupus familis
XP_547599
1258
142817
P756
I
I
N
S
P
L
P
P
V
S
S
P
P
P
A
Cat
Felis silvestris
Mouse
Mus musculus
Q6PF93
887
101469
P452
I
I
T
N
P
L
P
P
V
A
S
P
P
P
A
Rat
Rattus norvegicus
O88763
887
101516
P452
I
I
T
N
P
L
P
P
V
A
S
P
P
P
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6AZN6
886
101139
A451
I
L
S
N
P
L
P
A
V
S
S
P
A
P
P
Zebra Danio
Brachydanio rerio
NP_001017550
726
82679
K331
T
Q
E
K
A
L
T
K
F
L
K
C
V
N
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477133
949
107871
P510
T
P
G
S
S
S
L
P
C
D
S
N
S
N
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
G551
T
A
N
R
S
R
I
G
E
N
G
A
R
I
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
A419
A
L
Q
N
I
E
L
A
S
F
L
R
W
Y
V
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
L447
K
L
S
G
D
S
M
L
L
S
T
S
H
A
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.1
99.5
69.7
N.A.
97.9
98
N.A.
N.A.
N.A.
92
69.7
N.A.
55.9
N.A.
20
N.A.
Protein Similarity:
100
85.3
99.8
69.9
N.A.
98.9
99.4
N.A.
N.A.
N.A.
96.2
76.4
N.A.
71.9
N.A.
37.9
N.A.
P-Site Identity:
100
0
93.3
86.6
N.A.
80
80
N.A.
N.A.
N.A.
60
6.6
N.A.
20
N.A.
0
N.A.
P-Site Similarity:
100
13.3
93.3
86.6
N.A.
93.3
93.3
N.A.
N.A.
N.A.
86.6
6.6
N.A.
20
N.A.
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.8
36.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
60.4
55.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
0
0
9
0
0
17
0
17
0
9
9
9
50
% A
% Cys:
0
0
0
0
0
0
0
0
9
0
0
9
0
0
0
% C
% Asp:
0
0
0
0
17
0
0
9
0
9
0
0
0
0
0
% D
% Glu:
0
0
9
0
0
9
9
0
9
0
9
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
9
9
0
0
0
0
0
% F
% Gly:
0
0
9
9
0
0
0
9
0
0
9
0
0
0
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% H
% Ile:
50
42
0
0
9
0
9
0
0
0
0
0
0
9
0
% I
% Lys:
9
9
0
9
0
0
0
9
0
0
9
0
0
0
0
% K
% Leu:
0
25
0
0
0
59
17
9
9
17
9
9
9
0
0
% L
% Met:
0
0
0
9
0
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
17
34
0
0
0
0
0
9
0
9
0
17
9
% N
% Pro:
0
9
9
0
50
0
50
42
0
0
0
50
42
50
9
% P
% Gln:
0
9
9
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
9
0
9
0
0
0
0
0
9
9
0
0
% R
% Ser:
0
0
17
34
17
17
0
9
17
42
59
9
9
9
9
% S
% Thr:
25
0
34
0
0
0
9
0
0
0
9
0
0
0
0
% T
% Val:
0
0
0
0
0
9
0
0
50
0
0
0
9
0
9
% V
% Trp:
9
0
0
0
0
0
0
0
0
0
0
0
9
0
9
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _