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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3C3
All Species:
31.82
Human Site:
T668
Identified Species:
63.64
UniProt:
Q8NEB9
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NEB9
NP_002638.2
887
101549
T668
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
Chimpanzee
Pan troglodytes
XP_001142269
757
86303
L555
F
V
D
R
L
V
H
L
M
K
A
V
Q
R
E
Rhesus Macaque
Macaca mulatta
XP_001082892
887
101541
T668
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
Dog
Lupus familis
XP_547599
1258
142817
T972
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
Cat
Felis silvestris
Mouse
Mus musculus
Q6PF93
887
101469
T668
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
Rat
Rattus norvegicus
O88763
887
101516
T668
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6AZN6
886
101139
T667
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
Zebra Danio
Brachydanio rerio
NP_001017550
726
82679
K524
Q
A
L
L
K
G
D
K
S
V
R
V
M
R
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477133
949
107871
T730
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
N956
Q
V
G
T
G
F
M
N
T
A
V
R
S
I
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
F612
H
D
E
G
M
L
E
F
I
P
S
R
S
L
A
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
T656
E
N
V
D
L
K
L
T
P
Y
K
I
L
A
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.1
99.5
69.7
N.A.
97.9
98
N.A.
N.A.
N.A.
92
69.7
N.A.
55.9
N.A.
20
N.A.
Protein Similarity:
100
85.3
99.8
69.9
N.A.
98.9
99.4
N.A.
N.A.
N.A.
96.2
76.4
N.A.
71.9
N.A.
37.9
N.A.
P-Site Identity:
100
13.3
100
100
N.A.
100
100
N.A.
N.A.
N.A.
100
13.3
N.A.
100
N.A.
0
N.A.
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
N.A.
N.A.
100
40
N.A.
100
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.8
36.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
60.4
55.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
86.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
100
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
0
0
0
0
9
9
0
0
67
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
9
67
0
0
9
0
0
0
0
0
0
0
9
% D
% Glu:
67
0
9
0
0
0
9
0
0
0
0
0
0
0
9
% E
% Phe:
9
0
0
0
0
9
0
9
0
0
0
0
0
0
0
% F
% Gly:
0
0
9
9
9
9
0
0
0
0
0
0
0
0
0
% G
% His:
9
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
9
0
0
9
0
9
0
% I
% Lys:
0
0
0
0
9
67
0
9
0
9
67
0
0
0
0
% K
% Leu:
0
0
67
9
75
9
67
9
0
0
0
0
67
9
0
% L
% Met:
0
0
0
0
9
0
9
0
9
0
0
0
9
0
0
% M
% Asn:
0
67
0
0
0
0
0
9
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
67
9
0
0
0
0
0
% P
% Gln:
17
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% Q
% Arg:
0
0
0
9
0
0
0
0
0
0
9
17
0
17
0
% R
% Ser:
0
0
0
0
0
0
0
0
9
0
9
0
17
0
9
% S
% Thr:
0
0
0
9
0
0
0
67
9
0
0
0
0
0
67
% T
% Val:
0
17
9
0
0
9
0
0
0
9
9
75
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
67
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _