KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3C3
All Species:
22.12
Human Site:
Y395
Identified Species:
44.24
UniProt:
Q8NEB9
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NEB9
NP_002638.2
887
101549
Y395
D
D
E
D
L
L
M
Y
L
L
Q
L
V
Q
A
Chimpanzee
Pan troglodytes
XP_001142269
757
86303
T305
I
I
V
S
Y
P
P
T
K
Q
L
T
Y
E
E
Rhesus Macaque
Macaca mulatta
XP_001082892
887
101541
Y395
D
D
E
D
L
L
M
Y
L
L
Q
L
V
Q
A
Dog
Lupus familis
XP_547599
1258
142817
Y699
D
D
E
D
L
L
M
Y
L
L
Q
L
V
Q
A
Cat
Felis silvestris
Mouse
Mus musculus
Q6PF93
887
101469
Y395
D
D
E
D
L
L
M
Y
L
L
Q
L
V
Q
A
Rat
Rattus norvegicus
O88763
887
101516
Y395
D
D
E
D
L
L
M
Y
L
L
Q
L
V
Q
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6AZN6
886
101139
M394
A
D
D
E
D
L
L
M
Y
L
L
Q
L
V
Q
Zebra Danio
Brachydanio rerio
NP_001017550
726
82679
R274
S
K
H
H
R
L
A
R
S
L
R
S
G
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477133
949
107871
L453
L
S
A
T
S
S
G
L
H
G
S
V
I
P
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
S494
Y
M
K
D
M
P
P
S
A
V
L
S
I
R
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
F362
L
E
L
L
S
P
L
F
E
S
E
E
V
R
A
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
Y390
K
N
L
S
V
R
S
Y
A
V
N
R
L
K
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.1
99.5
69.7
N.A.
97.9
98
N.A.
N.A.
N.A.
92
69.7
N.A.
55.9
N.A.
20
N.A.
Protein Similarity:
100
85.3
99.8
69.9
N.A.
98.9
99.4
N.A.
N.A.
N.A.
96.2
76.4
N.A.
71.9
N.A.
37.9
N.A.
P-Site Identity:
100
0
100
100
N.A.
100
100
N.A.
N.A.
N.A.
20
13.3
N.A.
6.6
N.A.
6.6
N.A.
P-Site Similarity:
100
6.6
100
100
N.A.
100
100
N.A.
N.A.
N.A.
46.6
26.6
N.A.
20
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.8
36.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
60.4
55.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
9
0
0
0
9
0
17
0
0
0
0
0
59
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
42
50
9
50
9
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
9
42
9
0
0
0
0
9
0
9
9
0
9
9
% E
% Phe:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
9
0
0
9
0
0
9
0
0
% G
% His:
0
0
9
9
0
0
0
0
9
0
0
0
0
0
0
% H
% Ile:
9
9
0
0
0
0
0
0
0
0
0
0
17
0
0
% I
% Lys:
9
9
9
0
0
0
0
0
9
0
0
0
0
9
9
% K
% Leu:
17
0
17
9
42
59
17
9
42
59
25
42
17
0
0
% L
% Met:
0
9
0
0
9
0
42
9
0
0
0
0
0
0
0
% M
% Asn:
0
9
0
0
0
0
0
0
0
0
9
0
0
0
0
% N
% Pro:
0
0
0
0
0
25
17
0
0
0
0
0
0
17
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
9
42
9
0
42
9
% Q
% Arg:
0
0
0
0
9
9
0
9
0
0
9
9
0
17
0
% R
% Ser:
9
9
0
17
17
9
9
9
9
9
9
17
0
0
9
% S
% Thr:
0
0
0
9
0
0
0
9
0
0
0
9
0
0
0
% T
% Val:
0
0
9
0
9
0
0
0
0
17
0
9
50
9
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
9
0
0
50
9
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _